Product Identification

Product Name

2,4-Dimethoxyaniline

Synonyms

1-Amino-2,4-dimethoxybenzene
2,4-Dimethoxybenzenamine

CAS

2735-04-8

Formula

C8H11NO2

Molecular Weight

153.19999999999999

EINECS

220-355-7

RTECS

BX4200000

RTECS Class

Mutagen

Beilstein/Gmelin

638704

Beilstein Reference

4-13-00-02529

Physical and Chemical Properties

Appearance

Dark brown solid.

Solubility in water

7 g/L (20 C)

Melting Point

39

Boiling Point

262

Vapor Pressure

0.008 (25 C0

pKa/pKb

8.86 (pKb)

Partition Coefficient

.78

Heat Of Vaporization

50.5 kJ/mol

Usage

Chemical intermediate for c.I. Basic yellow 11.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed. Do not expose to air. Store protected from light. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Handle under an inert atmosphere. Store protected from air.

Hazards Identification

Inhalation

May cause respiratory tract irritation. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 20/21/22 33

EC Safety Phrase

S 22 36/37

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Possible cancer hazard based on tests with laboratory animals. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death.

Fire Fighting Measures

Flash Point

125

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.

Stability and Reactivity

Incompatibilities

Acids, acid chlorides, acid anhydrides, air, chloroformates, strong oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2810

Hazard Class

6.1

Packing Group

I; II; III