Product Identification

Product Name

Ulobetasol propionate

Synonyms

Pregna-1,4-diene-3,20-dione, 21-chloro-6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6-alpha,11-beta,16-beta)
Ulobetasol propionate
Ultravate

CAS

66852-54-8

Formula

C25H31ClF2O5

Molecular Weight

484.97

RTECS

TU3723500

Merck

12,4625

Physical and Chemical Properties

Appearance

Distributed as 0.05% ointment.

Solubility in water

Insoluble

Melting Point

220 - 221

Vapor Pressure

2.1E-15 (25 C)

Density

1.31 g/cm3 (20 C)

pKa/pKb

12.58 (pKa)

Partition Coefficient

3.73

Usage

Topical corticosteroid.

First Aid Measures

Ingestion

Give 2-4 cups of milk or water to dilute. Never give anything by mouth to an unconscious person.

Inhalation

Not applicable with normal use. In cases of overexposure, remove to fresh air. If breathing is difficult, give oxygen. If breathing has stopped, give artificial respiration. Contact a physician.

Skin

Wash immediately and thoroughly with soap and water. If redness, itching or burning sensation develops, get medical attention.

Eyes

Flush immediately with plenty of water for at least 15 minutes.

Handling and Storage

Storage

Product should be stored in cool, dry place, away from sources of heat. Store between 15 and 30 C.

Fire Fighting Measures

Fire Fighting

Extinguishing agents: Water, Carbon Dioxide, Dry Chemical, Foam. Wear self-contained breathing apparatus.

Accidental Release Measures

Small spills/leaks

Assure slippery conditions are nullified. Add sand or dirt. Scoop up and remove to plastic-lined fiber containers immediately. Dispose of in accordance with federal, state and local regulations.

Stability and Reactivity

Incompatibilities

Oxidizing agents, bases.

Stability

stable at normal temperatures and pressures.

Exposure Controls/Personal Protection

Exposure Effects

May cause irritation of skin and eyes. May cause mutagen and reproductive effects. May cause suppression of HPA axis, gastrointestinal upset and temporary CNS depression. Kidney disorders, hypersensitivity to any of the components.