Product Identification

Product Name

Molinate

Synonyms

Ethyl 1-Hexamethyleneiminecarbothiolate
Jalan
S-Ethyl azepane-1-carbothioate
S-Ethyl hexahydro-1H-azepine-1-carbothioate
s-Ethyl-n-hexahydro-1h-azepinthiolcarbamat

CAS

2212-67-1

Formula

C9H17NOS

Molecular Weight

187.33

EINECS

218-661-0

RTECS

CM2625000

RTECS Class

Agricultural Chemical and Pesticide; Mutagen; Reproductive Effector

Beilstein/Gmelin

1239196

Beilstein Reference

5-20-04-00034

EC Index Number

613-051-00-4

EC Class

Harmful

Physical and Chemical Properties

Appearance

Clear liquid with aromatic odor.

Solubility in water

970 mg/L (25 C)

Boiling Point

202

Vapor Pressure

0.0057 (25 C)

Density

1.063 g/cm3 (20 C)

Partition Coefficient

3.21

Usage

Herbicide.

Refractive Index

1.5092 (25 C)

First Aid Measures

Ingestion

Ipecac induced vomiting is not recommended because of the potential for cns depression and seizures. Consider after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion (generally within 1 hour). Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Intravenous fluids may be useful in restoring extracellular fluid volume following severe vomiting and diarrhea. Oxygen therapy is effective in relieving the distress of antabuse-like reactions rarely associated with exposure to thiram and possibly the mbdt-carb compounds. No specific antidotes are available for poisoning by these compounds. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.

Inhalation

Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.

Skin

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Store away from food and feedstuffs and out of reach of children.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory failure, requiring ventilatory support, has been reported following ingestions.

Skin

Exposure to dusts, sprays, solutions, wettable powder suspensions or emulsions of these agents may lead to skin and mucous membrane irritation.

Ingestion

Nausea, vomiting and diarrhea may occur.

Exposure Controls/Personal Protection

Personal Protection

Wear protective clothing; wash it thoroughly after use.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Exposure to thiram or mbdt-carb (based on animal studies) may cause weakness, ataxia, ascending paralysis and hypothermia. Peripheral neuropathy (pain, numbness and weakness of the extremities) has been noted following exposure to thiuram (the ethyl analog of thiram). No adverse reproductive effects (testicular parameters) in male mice were observed following methyl thiophanate doses up to 1000 mg/kg orally for 5 consecutive days (Traina et al, 1998). Maternal toxicity was evident in female rats.

Poison Class

4

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Fire Potential

Fire point= 143 C.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

Stable at 100 C for 16 hours apparently indefinite storage life under ambient conditions; photosensitivity is indeterminant relatively stable to hydrolysis by acids and alkalies. Stable @ < 200 C.

Incompatibilities

Strong oxidizing agents.