Product Identification

Product Name

4-Methoxyphenyl isocyanate

Synonyms

1-Isocyanato-4-methoxybenzene
4-Anisyl isocyanate
4-Isocyanatoanisole
p-Methoxyphenyl isocyanate

CAS

5416-93-3

Formula

C8H7NO2

Molecular Weight

149.15

EINECS

226-513-1

Beilstein/Gmelin

471920

Beilstein Reference

4-13-00-01206

Physical and Chemical Properties

Appearance

Clear, colorless liquid.

Solubility in water

Insoluble

Boiling Point

106

Density

1.1559 g/cm3 (20 C)

Refractive Index

1.55 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. May cause asthmatic attacks due to allergic sensitization of the respiratory tract.

Skin

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause severe irritation and possible burns.

Eyes

Contact with eyes may cause severe irritation, and possible eye burns. Lachrymator.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.

EC Risk Phrase

R 23/25 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

3080

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic inhalation may cause effects similar to those of acute inhalation.

Fire Fighting Measures

Flash Point

98

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Most foams will react with the material and release corrosive/toxic gases.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Use water spray to disperse the gas/vapor. A vapor suppressing foam may be used to reduce vapors.

Stability and Reactivity

Stability

No data.

Incompatibilities

Water - alcohols - strong bases - amines - acids - heat - strong oxidizing agents.

Decomposition

Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3080

Hazard Class

6.1

Packing Group

II