Product Identification

Product Name

L-Cinchonidine

Synonyms

(8a,9R)-Cinchonan-9-ol
(8S,9R)-Cinchonidine
(R)-[(4S,5R,7S)-5-Ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-quinolin-4-ylmethanol
a-Quinidine

CAS

485-71-2

Formula

C19H22N2O

Molecular Weight

294.39999999999998

EINECS

207-622-3

RTECS

GD2975000

RTECS Class

Drug; Natural Product

Merck

13,2307

Beilstein/Gmelin

89690

Beilstein Reference

5-23-12-00406

Physical and Chemical Properties

Appearance

White to cream powder.

Solubility in water

Insoluble

Melting Point

199 - 202

Boiling Point

465

Vapor Pressure

2E-9 (25 C)

Density

1.22 g/cm3

pKa/pKb

4.82 (pKb)

Partition Coefficient

3.35

Heat Of Vaporization

76.5 kJ/mol

Usage

Antimalarial agent.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

EC Risk Phrase

R 22

EC Safety Phrase

S 22 36/37

UN (DOT)

1544

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

235

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Transport Information

UN Number

1544

HS Code

2939 29 00