Product Identification

Product Name

Ketanserin

Synonyms

2,4(1H,3H)-Quinazolinedione, 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-
3-[2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione

CAS

74050-98-9

Formula

C22H22FN3O3

Molecular Weight

395.43

EINECS

277-680-2

Merck

12,5307

Physical and Chemical Properties

Appearance

White to off-white solid.

Solubility in water

Insoluble

Melting Point

231

Density

1.28 g/cm3 (20 C)

pKa/pKb

6.26 (pKb)

Partition Coefficient

3.21

Usage

Classified as an antihypertensive, serotonin antagonist.

First Aid Measures

Ingestion

Remove dentures and clear mouth. If person is conscious, rinse mouth with water. Call physician or poison control immediately.

Inhalation

Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops, administer artificial respiration. Seek medical attention immediately.

Skin

Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes. Seek medical attention immediately.

Eyes

Check for and remove contact lenses. Flush eyes with running water for at least 15 minutes separating eyelids. Seek medical attention immediately

Handling and Storage

Storage

This product should be stored at room temperature. It should be kept in a tightly closed container.

Exposure Controls/Personal Protection

Personal Protection

For spill clean up, wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or NIOSH/MSHA approved respirator is required.

Exposure Effects

May be harmful if ingested, inhaled, or absorbed through the skin. Symptoms of overexposure can include: low blood pressure, light-headedness, sedation, tremor, convulsions or vomiting.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, dry chemical powder, polymer foam, water spray. Use self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Wipe up spill and place in sealed container and hold for disposal. Avoid raising dust. Ventilate the area and wash spill site after material has been removed.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable if stored as directed.

Combustion Products

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Fluorine, Hydrogen fluoride.