Product Identification

Product Name

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether

Synonyms

17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
17a-Ethynylestradiol 3-cyclopentyl ether17a-ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-cyclopentyl ether
19-Nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol, 3-(cyclopentyloxy)-
3-(Cyclopentyloxy)-19-nor-17a-pregna-1,3,5(10)-trien-20-yn-17-ol

3-Cyclopentyloxy-17a-ethynyl-1,3,5(10)-estratrien-17-ol
Ethynylestradiol-3-cyclopentyl ether

CAS

152-43-2

Formula

C25H32O2

Molecular Weight

364.53

EINECS

205-803-1

RTECS

RC8948000

RTECS Class

Drug; Reproductive Effector; Human Data; Hormone

Merck

12,8239

Beilstein/Gmelin

2013312

Beilstein Reference

5-06

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

107 - 108

Vapor Pressure

6E-11 (25 C)

pKa/pKb

13.10 (pKa)

Partition Coefficient

5.4

Heat Of Vaporization

81.3 kJ/mol

Usage

Used to treat symptoms of menopause, such as hot flashes. Also used to treat breast and prostate cancer.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.

Exposure Effects

Toxic. May cause cancer. Harmful by inhalation, in contact with skin and if swallowed. May cause harm to the unborn child. Reproductive hazard. Target organ(s): Liver. Blood.

Fire Fighting Measures

Flash Point

219

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide.

Hazards Identification

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

45 61 20/21/22

EC Safety Phrase

53 22 36/37/39 45