Product Identification

Product Name

trans-Diammineplatinum(II) dichloride

Synonyms

NSC 131558
trans-Diamminedichloroplatinum
trans-Diamminedichloroplatinum(II)
trans-Dichlorodiammineplatinum(II)
trans-Platinum(II)diamminedichloride

CAS

14913-33-8

Formula

Cl2H6N2Pt

Molecular Weight

300.04000000000002

EINECS

238-980-9

RTECS

TP2455000

RTECS Class

Tumorigen; Drug; Mutagen

Beilstein/Gmelin

2520 (G)

Physical and Chemical Properties

Appearance

Deep yellow crystals.

Solubility in water

Slightly soluble

Melting Point

340

Density

3.746 g/cm3

Usage

After undergoing hydrolysis, it reacts with dna to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of dna.

Refractive Index

1.706

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

UN (DOT)

3288

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Possible risk of irreversible effects.

Exposure limit(s)

IDHL: 4 mg/m3

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Non-Combustible

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen chloride, nitrogen oxides, irritating and toxic fumes and gases, nitrogen.

Combustion Products

Toxic gases and vapors (such as chlorine) may be released when chlorine-containing soluble platinum salts decompose.

Transport Information

UN Number

3288

Hazard Class

6.1

Packing Group

I; II; III