Product Identification

Product Name

4-Piperidinecarboxylic acid methyl ester

Synonyms

4-(Methoxycarbonyl)piperidine
4-Piperidinecarboxylic acid, methyl ester
Methyl isonipecotate
Methyl isonipecotinate
Methyl piperidine-4-carboxylate

CAS

2971-79-1

Formula

C7H13NO2

Molecular Weight

143.18

Beilstein Reference

4-22-00-00128

Physical and Chemical Properties

Solubility in water

39 g/L (25 C)

Melting Point

50

Boiling Point

194

Vapor Pressure

0.46 (25 C)

Density

1.06 g/cm3 (25 C)

pKa/pKb

3.77 (pKb)

Partition Coefficient

.38

Heat Of Vaporization

42.99 kJ/mol

Refractive Index

1.4635 (25^oC)

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Keep away from heat and open flame. Store in a cool dry place.

Hazards Identification

Skin

Causes irritation.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

36/37/38

EC Safety Phrase

26 36

UN (DOT)

1993

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Exposure Effects

Vapor or mist is irritating to the eyes, mucous membranes, and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption.

Fire Fighting Measures

Flash Point

89

Fire Fighting

For small (incipient) fires, use media such as 'alcohol' foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Combustible liquid.

Accidental Release Measures

Small spills/leaks

Absorb on sand or vermiculite and place in closed containers for disposal. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Oxides of carbon, oxides of nitrogen.

Transport Information

UN Number

1993

Hazard Class

3

Packing Group

III