Methyl isonipecotate Chemical Properties

Boiling point:

85-90 °C (lit.)

Density 

1.06 g/mL at 25 °C (lit.)

refractive index 

1.465

Flash point:

192°F

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility 

Chloroform

form 

Liquid

pka

9.78±0.10(Predicted)

color 

Colorless to yellow

Water Solubility 

Slightly soluble in water.

CAS DataBase Reference

2971-79-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

3267

WGK Germany 

3

HS Code 

29333990

MSDS

• Language:English Provider:4-Piperidinecarboxylic acid methyl ester

Methyl isonipecotate Usage And Synthesis

Chemical Properties

Colorless liquid

Uses

Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.

Uses

Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.

Uses

4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.

General Description

Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.

Methyl isonipecotate(2971-79-1)Related Product Information

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