Product Identification

Product Name

4-Methoxybenzeneamine

Synonyms

1-Amino-4-methoxybenzene
4,4''-Diaminoterphenyl
4-[4-(4-Aminophenyl)phenyl]aniline
4-Methoxyaniline
p,p'-Diaminoterphenyl

CAS

104-94-9

CAS

3365-85-3

Formula

C18H16N2

Formula

C7H9NO

Molecular Weight

260.33999999999997

Molecular Weight

123.16

EINECS

203-254-2

RTECS

BZ5450000

RTECS Class

Tumorigen; Drug; Mutagen

Merck

13,670

Beilstein/Gmelin

2120295

Beilstein/Gmelin

471556

Beilstein Reference

4-13-00-00480

Beilstein Reference

4-13-00-01015

EC Index Number

612-112-00-2

EC Class

Very toxic; Danger of cumulative effects; Dangerous for the Environment

Physical and Chemical Properties

Appearance

White, fused crystalline solid, characteristic amine odor. May darken on exposure to light and air.

Solubility in water

Soluble

Melting Point

55 - 58

Melting Point

248 - 249

Boiling Point

243

Boiling Point

440

Vapor Pressure

0.03 (25 C)

Density

1.2 g/cm3 (20 C)

pKa/pKb

9.79 (pKb)

Partition Coefficient

.95

Partition Coefficient

3.78

Heat Of Vaporization

34.3 kJ/mol

Heat Of Combustion

-3571 kJ/mol

Usage

In the manufacture of azo dyes.

Vapor Density

4.25

Refractive Index

1.5559 (60 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Ingestion

Seek medical assistance.

Inhalation

TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Effects of contact or inhalation may be delayed.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.

Skin

Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Get medical aid if symptoms occur.

Skin

Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.

Eyes

See Inhalation.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Eyes

Immediately flush with running water for at least 20 minutes.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.

Hazards Identification

Ingestion

See Inhalation.

Inhalation

May cause severe allergic respiratory reaction. May cause respiratory tract irritation. Effects of inhalation may be delayed.

Skin

May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, may cause symptoms similar to those for ingestion. Effects of contact may be delayed. May cause contact dermatitis.

Eyes

Causes severe eye irritation.

Ingestion

May cause irritation of the digestive tract. May cause kidney damage. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 26/27/28 33 50

EC Risk Phrase

R 45 20/21/22

EC Safety Phrase

S 28 36/37 45 61

EC Safety Phrase

S 53 45

UN (DOT)

2431

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause cancer according to animal studies.

Exposure limit(s)

OSHA PEL: TWA 0.5 mg/m3

Poison Class

1*

Fire Fighting Measures

Flash Point

105

Autoignition

450

Fire Fighting

Extinguish using agent most appropriate for surrounding fire.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. May polymerize explosively when involved in a fire. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Do NOT get water inside containers. Cool containers with flooding quantities of water until well after fire is out.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Fire Potential

This chemical is flammable.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Small spills/leaks

ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.

Stability and Reactivity

Disposal Code

9

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2431

UN Number

2811

Hazard Class

6.1

Packing Group

III

HS Code

2922 22 00