Product Identification

Product Name

Pancuronium bromide

Synonyms

2b,16b-Dipiperidino-5a-androstane-3a,17b-diol diacetate dimethobromide
Mioblock
Pavulon
Piperidinium, 1,1'-[(2b,3a,5a,16b,17b)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide

CAS

15500-66-0

Formula

C35H60Br2N2O4

Molecular Weight

732.68

EINECS

239-532-5

RTECS

TN4930000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7139

Beilstein/Gmelin

4121757

Beilstein Reference

5-20-03-00259

Physical and Chemical Properties

Appearance

White to near-white, hydroscopic crystalline powder with no odor.

Melting Point

214 - 217

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Pancuronium bromide should be stored under refrigeration at 2-8C. Keep container tightly closed.

Handling

When protective clothing and respirator when handling this material.

Hazards Identification

Inhalation

Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.

Skin

Absorbed through wonds and skin defects. Paralysis with risk of respiratory failure.

Ingestion

Prolonged apnea and respiratory arrest may be noted due to paralysis of the intercostal muscles and diaphragm.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant (rubber) gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

A supplied (purified) air respirator, hood fit type, breathable air via hose.

Exposure Effects

paralysis of skeletal muscle results in heaviness of the eyelids, difficulty in swallowing and talking, diplopia, progressive weakness of the extremities, the neck, intercostals and diaphragm. Tubocurarine does not penetrate the blood brain barrier hence few CNS effects are noted.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Sweep up carefully and transfer to a container and tightly seal. Wear protective equipment.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen bromide.