Product Identification

Product Name

3-Chlorophenol

Synonyms

3-Chloro-1-hydroxybenzene
3-Chlorophenol
3-Hydroxychlorobenzene

CAS

108-43-0

Formula

C6H5ClO

Molecular Weight

128.56

EINECS

203-582-6

RTECS

SK2450000

RTECS Class

Tumorigen; Mutagen

Merck

13,2173

Beilstein/Gmelin

1634401

Beilstein Reference

4-06-00-00810

EC Index Number

604-008-00-0

EC Class

Harmful; Dangerous for the Environment

Physical and Chemical Properties

Appearance

White, needle-like crystals, distinct odor, similar to phenol. Some discoloration on exposure to light and air.

Solubility in water

26 g/L

Melting Point

31 - 34

Boiling Point

214

Vapor Pressure

1

Density

1.245 g/cm3 (20 C)

pKa/pKb

9.12 (pKa)

Partition Coefficient

2.5

Heat Of Vaporization

69.4 kJ/mol

Usage

Intermediate in organic synthesis.

Saturation Concentration

6580 ppm (0.66%) at 72 C (calculated)

Odor threshold

0.18 ppb

Refractive Index

1.5565 (40 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 20/21/22 51/53

EC Safety Phrase

S 28 61

UN (DOT)

2020

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.

Exposure Effects

Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.

Poison Class

3

Fire Fighting Measures

Flash Point

97

Autoignition

> 600

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Upper exp. limit

8.8

Lower exp. limit

1.7

Fire Potential

This chemical is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Oxidizing agents, acid chlorides, acid anhydrides, moisture.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2020

Hazard Class

6.1

Packing Group

III

HS Code

2908 10 00