Product Identification

Product Name

2-Amino-2-(hydroxymethyl)-1,3-propanediol

Synonyms

2-Amino-2-(hydroxymethyl)-1,3-propanediol
2-Amino-2-(hydroxymethyl)propane-1,3-diol
Aminotris(hydroxymethyl)methane
Tham
Tris(hydroxymethyl)methylamine
Tromethanmin

CAS

77-86-1

Formula

C4H11NO3

Molecular Weight

121.14

EINECS

201-064-4

RTECS

TY2900000

RTECS Class

Drug

Merck

12,9902

Beilstein/Gmelin

741883

Beilstein Reference

4-04-00-01903

EC Class

irritant

Physical and Chemical Properties

Appearance

Crystalline mass or white, crystalline powder, slight characteristic amine odor, hygroscopic.

Solubility in water

Very soluble

Melting Point

131

Boiling Point

357

Vapor Pressure

2E-6 (25 C)

Density

1.328 g/cm3

pKa/pKb

6.22 (pKb)

Partition Coefficient

-1.38

Heat Of Vaporization

69.7 kJ/mol

Usage

In synth of surface-active agents, vulcanization accelerators, pharmaceuticals: titrimetric standard, as emulsifying agent for cosmetic creams & lotions, mineral oil & paraffin wax emulsions, leather dressings, emulsifying agent for textile specialties, polishes, cleaning compd, so-called sol oils.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep away from acids. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Discard contaminated shoes.

Hazards Identification

Inhalation

May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns.

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 26 36

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Prolonged or repeated skin contact may cause dermatitis.

Poison Class

-

Fire Fighting Measures

Flash Point

170

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal.

Stability and Reactivity

Disposal Code

28

Incompatibilities

Bases, oxidizing agents, acids, aldehydes, copper, brass, and aluminum.

Stability

Stable under normal temperatures and pressures.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Transport Information

HS Code

2922 19 80