Product Identification

Product Name

2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride

Synonyms

1-(2-Morpholinoethyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester
2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride
2-Butoxy-N-[2-diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride
4-Piperidinecarboxylic acid, 1-[2-(4-morpholinyl)ethyl]-4-phenyl-, ethyl ester
Benzolin
Cinchocaine hydrochloride
Isonipecotic acid, 1-(2-morpholinoethyl)-4-phenyl-, ethyl ester
Morpholinoethyl morpethidine
Nupercaine hydrochloride

CAS

469-81-8

CAS

61-12-1

Formula

C20H30ClN3O2

Formula

C20H30N2O3

Molecular Weight

379.93

Molecular Weight

346.47

EINECS

200-498-1

EINECS

207-422-6

RTECS

GD3325000

RTECS Class

Drug; Mutagen; Primary Irritant

Merck

12,6357

Merck

13,3057

Beilstein/Gmelin

3770332

Beilstein Reference

5-22-05-00278

Physical and Chemical Properties

Appearance

DEA controlled substance. DEA number 9632.

Solubility in water

0.21 g/L (25 C)

Solubility in water

330 g/L (37 C)

Melting Point

252

Melting Point

93 - 101

Boiling Point

441

Vapor Pressure

5.5E-8 (25 C)

Density

1.094 g/cm3 (20 C)

pKa/pKb

6.33 (pKb)

Partition Coefficient

2.11 (25 C)

Heat Of Vaporization

69.86 kJ/mol

Usage

A strong analgesic with around 4 times the potency of pethidine,[1] and unlike pethidine, does not cause convulsions, although it produces the standard opioid side effects such as sedation and respiratory depression.

Usage

Potent, long-acting local anesthetic.

Refractive Index

1.5502 (106 C)

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

Causes skin irritation. May be harmful if absorbed through the skin.

Eyes

Causes severe eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22

EC Safety Phrase

36

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Irritant. Irritating to respiratory system. Risk of serious damage to eyes. Photosensitizer. Target organ(s): Central nervous system. Cardiovascular system.

Fire Fighting Measures

Flash Point

220

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures. Protect from moisture.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.