Product Identification

Product Name

2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride

Synonyms

Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Becilan
Benadon

CAS

58-56-0

Formula

C8H12ClNO3

Molecular Weight

205.64

EINECS

200-386-2

RTECS

UV1350000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,8166

Beilstein/Gmelin

3632435

Beilstein Reference

5-21-05-00492

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

220 g/L (25 C)

Melting Point

212

Usage

Inhibitor of poly(ethylene glycol) oxidation.

Vapor Density

7.1

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.

Hazards Identification

Inhalation

May cause respiratory tract irritation. Low hazard for usual industrial handling.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Low hazard for usual industrial handling.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

The principal effect of pyridoxine overdosage is a sensory axonal neuropathy. Central effects have also been described. Neuropathy may also occur after a single extremely large parenteral dose, but the exact toxic amount is not well documented in humans. Exacerbation of seizure activity was reported in two encephalitis patients receiving intravenous pyridoxine. Seizures occur in animals given toxic doses.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.