Product Identification

Product Name

(R)-2-(Methylamino)succinic acid

Synonyms

(2R)-2-Methylaminobutanedioic acid
NMDA
N-Methyl D-aspartate

CAS

6384-92-5

Formula

C5H9NO4

Molecular Weight

147.13

RTECS

CI9457000

RTECS Class

Drug

Merck

12,6760

Beilstein/Gmelin

1724431

Beilstein Reference

3-04-00-01522

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Very soluble

Melting Point

192 - 194

pKa/pKb

2.28 (pKa)

Partition Coefficient

-1.15

Usage

An amino acid that, as the d-isomer, is the defining agonist for the nmda receptor subtype of glutamate receptors.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Do not store in direct sunlight. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. May be harmful if swallowed. May cause salicylism with effects similar to skin

Inhalation

May cause respiratory tract irritation. May be harmful if inhaled. May cause salicylism with effects similar skin absorption.

Skin

May cause skin irritation. May be harmful if absorbed through the skin. Absorption through the skin may cause salicylism, characterized by deep and rapid breathing, nausea, vomiting, tinnitis, gastrointestinal irritation with possible ulcers and possible strokes.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.