Product Identification

Product Name

L-Proline betaine

Synonyms

(1,1'-Biphenyl)-2-amine
(S)-2-Carboxy-1,1-dimethylpyrrolidinium hydroxide inner salt
1-Methylproline methylbetaine
2-Aminobiphenyl
2-Aminodiphenyl
Cadabine
Methyl hygrate betaine
o-Aminobiphenyl
o-Aminodiphenyl
o-Biphenylamine
Proline betaine
Pyrrolidinium, 2-carboxy-1,1-dimethyl-, inner salt, (2S)-

CAS

471-87-4

CAS

90-41-5

Formula

C12H11N

Formula

C7H13NO2

Molecular Weight

143.19

Molecular Weight

169.23

EINECS

201-990-9

EINECS

207-445-1

RTECS

DU8850000

RTECS Class

Mutagen

Merck

12,8926

Beilstein/Gmelin

471874

Beilstein Reference

4-12-00-03223

EC Index Number

612-142-00-6

EC Class

Carcinogenic Category 3; Harmful; Dangerous for the Environment

Physical and Chemical Properties

Appearance

Colorless or purplish crystals.

Solubility in water

Insoluble

Melting Point

268

Melting Point

42 - 44

Boiling Point

299

Vapor Pressure

0.001 (25 C)

Partition Coefficient

2.68

Heat Of Vaporization

53.9 kJ/mol

Heat Of Combustion

-6388 kJ/mol

Usage

Chemical intermediate for carbazole, resins, & synthetic rubbers.

Vapor Density

5.8

Refractive Index

 

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Dyspnea and tachypnea may occur.

Skin

Central cyanosis unresponsive to oxygen therapy is classic.

Eyes

See Inhalation.

Ingestion

Nausea and vomiting may occur.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 22 40 52/53

EC Safety Phrase

S 36/37 61

UN (DOT)

3259

Exposure Controls/Personal Protection

Personal Protection

If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Exposure Effects

CNS effects include headache, dizziness, altered mental status, confusion (lethargy progressing coma), seizures, syncope; occur secondary to CNS hypoxia, usually with levels > 20%.

Poison Class

4

Fire Fighting Measures

Flash Point

150

Autoignition

461

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This chemical is probably combustible.

Accidental Release Measures

Small spills/leaks

Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides..

Stability

No data.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3259

Hazard Class

8

Packing Group

I; II; III

HS Code

2921 49 80