Product Identification

Product Name

5-Aminouracil

Synonyms

2,4(1H,3H)-Pyrimidinedione, 5-amino-
2,4-Dihydroxy-5-aminopyrimidine
5-Amino-1H-pyrimidine-2,4-dione
5-Amino-2,4(1H,3H)-pyrimidinedione
5-Amino-2,4-dihydroxypyrimidine
-Amino-2,4-pyrimidinediol

CAS

932-52-5

Formula

C4H5N3O2

Molecular Weight

127.1

EINECS

213-252-3

RTECS

YQ8740000

RTECS Class

Mutagen

Beilstein/Gmelin

127250

Beilstein Reference

5-25-15-00428

Physical and Chemical Properties

Appearance

Tan powder.

Solubility in water

Very soluble

Melting Point

300

Boiling Point

377

pKa/pKb

4.80 (pKb)

Partition Coefficient

-2.49

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Do not expose to air. Store under an inert atmosphere.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Handle under an inert atmosphere. Store protected from air.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

EC Safety Phrase

S 22 24/25

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Laboratory experiments have resulted in mutagenic effects.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. Place under an inert atmosphere.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.