Product Identification

Product Name

Ubenimex

Synonyms

3-(R)-Amino-2-(S)-hydroxy-4-phenylbutanoyl-(S)-leucine
Bestatin
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
NK-421

CAS

58970-76-6

Formula

C16H24N2O4

Molecular Weight

308.38

EINECS

261-529-2

RTECS

OH2915000

RTECS Class

Drug; Reproductive Effector; Natural Product

Merck

12,9973

Beilstein/Gmelin

4704312

Beilstein Reference

6-14

Physical and Chemical Properties

Appearance

white powder

Solubility in water

Soluble

Melting Point

231 - 234

Vapor Pressure

2E-15 (25 C)

pKa/pKb

3.60 (pKa)

Heat Of Vaporization

94.5 kJ/mol

Usage

An aminopeptidase inhibitor used in combination with chemotherapeutics for the maintenance and enhancement of complete remission of acute non-lymphocytic leukemia in adults.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Safety Phrase

22 24/25

Exposure Controls/Personal Protection

Personal Protection

Protective gloves. Chemical safety goggles.

Respirators

Wear dust mask.

Exposure Effects

The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

Fire Fighting Measures

Flash Point

320

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.