3-Quinuclidinol(1619-34-7)
Product Identification
Product Name
3-Quinuclidinol
Synonyms
1-Azabicyclo(2.2.2)octan-3-ol
1-Azabicyclo[2.2.2]octan-8-ol
3-Hydroxyquinuclidine
CAS
1619-34-7
Formula
C7H13NO
Molecular Weight
127.18
EINECS
216-578-4
RTECS
VD6191700
RTECS Class
Mutagen
Merck
12,8266
Beilstein/Gmelin
104327
Beilstein Reference
5-21-01-00271
Physical and Chemical Properties
Appearance
Almost white crystalline powder.
Solubility in water
Very soluble
Melting Point
225 - 227
pKa/pKb
4.96 (pKb)
Partition Coefficient
-.09
Usage
Benzilate (ester) has been used as an incapacitating agent in chemical warfare: health aspects of chemical and biological weapons (who, geneva, 1970) pp 49-51.
First Aid Measures
Ingestion
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).
Handling and Storage
Storage
Keep container closed when not in use. Store in a cool, dry area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Use with adequate ventilation. Use only in a chemical fume hood. Discard contaminated shoes.
Hazards Identification
Inhalation
Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Inhalation may produce burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Skin
Causes skin burns.
Eyes
Causes eye burns. May cause chemical conjunctivitis and corneal damage.
Ingestion
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns.
EC Risk Phrase
R 34
EC Safety Phrase
S 26 36/37/39 45
UN (DOT)
3259
Exposure Controls/Personal Protection
Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
Effects may be delayed.
Fire Fighting Measures
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use carbon dioxide, dry chemical powder or appropriate foam.
Accidental Release Measures
Small spills/leaks
Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Cover with sand, dry lime or soda ash and place in a closed container for disposal. Absorb spill with an alkaline material such as soda ash or lime. Provide ventilation.