TIROFIBAN HYDROCHLORIDE MONOHYDRATE

Product Name: TIROFIBAN HYDROCHLORIDE MONOHYDRATE
CAS No.: 142373-60-2
Chemical Name: TIROFIBAN HYDROCHLORIDE MONOHYDRATE
Synonyms: Tirofiban Hydrochloride;butoxy);L 700462;4-Dihydroxypyridine;-3-(4-(4-(piperidin-4-yl);TirofibanhydrochlorideHCl;Tirofiban hydrochloride 1-hydrate;Tirofiban hydrochloride (L700462);Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride;N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride
CBNumber: CB0100160
Molecular Formula: C22H39ClN2O6S
Formula Weight: 495.07
MOL File: 142373-60-2.mol

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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Property

Melting point:: 83-87oC
solubility: Methanol (Slightly)
form: Solid
color: White
CAS DataBase Reference: 142373-60-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0014445
Product name: TIROFIBAN HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $501.15
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 53173
Product name: TirofibanHCl
Packaging: 10mg
Price: $570
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014445
Product name: TIROFIBAN HYDROCHLORIDE
Purity: 95.00%
Packaging: 250MG
Price: $898.8
Updated: 2021/12/16

Chemenu

Product number: CM195483
Product name: (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride
Purity: 97%
Packaging: 1g
Price: $1117
Updated: 2021/12/16

Crysdot

Product number: CD21014226
Product name: (S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoicacidhydrochloride
Purity: 97%
Packaging: 1g
Price: $1186
Updated: 2021/12/16

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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Chemical Properties,Usage,Production

Description

Tirofiban was launched as Aggrastat in Switzerland and the US for patients with unstable angina or non-Q-wave myocardial infarction to prevent cardiac ischemic events. Tirofiban is synthesized from (S)-tyrosine by a fourstep process. Tirofiban is a novel highly potent antiplatelet agent that inhibits the interaction of fibrinogen with GPⅡb/Ⅲa, an activated platelet membrane-bound glycoprotein complex. It prevents arterial thrombus formation in a dosedependent manner. Clinical efficacy was highly significant with an absolute and relative risk reduction. In these studies, treatment with tirofiban was well tolerated, without significant adverse effects.

Originator

Sibutramine (Sibutramine)

Uses

Aggrastat (Millot Laboratories, France).

Uses

Tirofiban Hydrochloride is a selective nonpeptide platelet glycoprotein IIb/IIIa antagonist.

Manufacturing Process

The synthesis of tirofiban starts by reaction of tyrosine with bis-trimethylsilyl trifluoraceramide to give a derivative in which both functions -OH and COOH_x0002_are protected. Treatment of this intermediate with butylsulfonyl chloride gives the corresponding sulfonamide derivative; the quite labile silyl groups are then removed under mildly acidic conditions to give N-butylsulfonyl-tyrosine. In a parallel scheme, 4-picoline is converted to its anion by means of butyl lithium; this gives 4-(4-chlorobutyl)-pyridine on alkylation with 1-bromo-3- chloropropane. The reaction of this compound with N-butylsulfonyl-tyrosine in presence of NaOH gives the ether 2-butylsulfonyaminol-3-[4-pyridin-4-ylbutoxy-phenyl]propionic acid. Hydrogenation over palladium on charcoal then reduce the pyridine ring to a piperidine to afford the fibrinogen receptor antagonist tirofiban.

brand name

Tirofiban is INN and BAN.

Therapeutic Function

Fibrinogen receptor antagonist

TIROFIBAN HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TIROFIBAN HYDROCHLORIDE MONOHYDRATE Suppliers

China 94 France 1 Germany 1 India 5 South Korea 1 United Kingdom 5 United States 11 Global 118

Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.

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BOC Sciences

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ChemStrong Scientific Co.,Ltd

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Chengdu Sino-Strong Pharmaceutical Co.,Ltd.

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Wuhan Dahua Pharmaceutical Co., Ltd.

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View Lastest Price from TIROFIBAN HYDROCHLORIDE MONOHYDRATE manufacturers

Dideu Industries Group Limited

Product: TIROFIBAN HYDROCHLORIDE MONOHYDRATE 142373-60-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-06

Shaanxi Dideu Medichem Co. Ltd

Product: Tirofiban hydrochloride 142373-60-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

Career Henan Chemical Co

Product: TIROFIBAN HYDROCHLORIDE MONOHYDRATE 142373-60-2
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

142373-60-2, TIROFIBAN HYDROCHLORIDE MONOHYDRATERelated Search:

Tirofiban hydrochloride monohydrate L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) tirofiban N-Butylsulfonyl-O-(4-(4-pyridinyl)butyl)-L-tyrosine 4-PYRIDIN-4-YL-BUTAN-1-OL 1-Butanesulfonic acid methyl ester 4-PYRIDIN-4-YL-BUTYRIC ACID Sodium 1-butanesulfonate 1-Methylethyl 1-butanesulfonate METHYL N-BUTYLSULFONYL-L-P-HYDROXYPHENYLALANINE tirofiban tirofiban 1-Butanesulfonyl chloride 4-(4-Piperidyl)-1-butanol 2-butyl-4-methylpyridine 4,4'-Dimethyl-2,2'-bipyridyl 4-Chloro-1-butanol

L 700462

L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride

N-(Butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride

2-(butylsulfonaMido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid

L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-, hydrochloride (1:1)

-3-(4-(4-(piperidin-4-yl)

butoxy)

N-(Butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-L-tyrosine hydrochloride

Tirofiban Hydrochloride

TirofibanhydrochlorideHCl

(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid hydrochloride

Tirofiban hydrochloride monohydrate Tirofiban Hydrochloride

2-(butylsulfonylamino)-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic acid hydrochloride

(S)-2-(Butylsulfonamido)-3-(4-(4-(piperidin-4-yl)butoxy)phenyl)propanoic acid

Tirofiban hydrochloride 1-hydrate

Tirofiban hydrochloride (L700462)

4-Dihydroxypyridine

142373-60-2

C22H36N2O5SHCl

C22H36N2O5SHClH2O

C22H39ClN2O6S

C23H40ClNO6S

C22H36N2O5SClH