Ponazuril

Product Name: Ponazuril
CAS No.: 69004-04-2
Chemical Name: Ponazuril
Synonyms: 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;Veterinary Ponazuril;Toltrazuril Sulfone Standard;Toltrazuril sulfone Ponazuril;Ponazuril ，Toltrazuril sulfone
CBNumber: CB01075339
Molecular Formula: C18H14F3N3O6S
Formula Weight: 457.38
MOL File: 69004-04-2.mol

More

Less

Ponazuril Property

Melting point:: 242°
Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 6.46±0.20(Predicted)
color: White to Off-White
InChIKey: VBUNOIXRZNJNAD-UHFFFAOYSA-N
CAS DataBase Reference: 69004-04-2

More

Less

Safety

WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33816
Product name: Toltrazuril sulfone
Purity: VETRANAL
Packaging: 10mg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 250mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 100mg
Price: $169
Updated: 2024/03/01

More

Less

Ponazuril Chemical Properties,Usage,Production

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Ponazuril Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ponazuril Suppliers

Canada 1 China 119 Germany 2 India 2 Switzerland 1 United Kingdom 1 United States 18 Global 144

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14059
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

More

Less

View Lastest Price from Ponazuril manufacturers

Sinoway Industrial co., ltd.

Product: Ponazuril ，Toltrazuril sulfone 69004-04-2
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2022-08-25

Hebei Ganmiao New material Technology Co., LTD

Product: Ponazuril 69004-04-2
Price: US $10.00-8.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-06

Anhui Yiao New Material Technology Co., Ltd

Product: Toltrazuril sulfone 69004-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 tons
Release date: 2023-11-02

69004-04-2, PonazurilRelated Search:

D-Nebivolol,hydrochloride(1:1) Nebivolol Impurity 2 HCl (SR,RS) (+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol Defluoro Nebivolol (Mixture of DiastereoMers) Didefluoro Nebivolol (Mixture of DiastereoMers) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran (-)-Nebivolol Nebivolol Impurity 28 HCl (SS,RS) Nebivolol Impurity 3 Nebivolol Impurity 13 HCl (SS,SS) (2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran Toltrazuril 4-(Trifluoromethylthio)phenol 1-Methyl-3-{3-methyl-4-[4-(trifluormethylsulfinyl)-phenoxy]-phenyl}-1,3,5-triazin-2,4,6(1H,3H,5H)-trion 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE Ponazuril 1-Methanesulfonyl-4-phenoxy-benzene 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE

Toltrazuril sulfone Ponazuril

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H

Ponazuril

ToltrazurilSulfone

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Ponazuril [inn]

Unii-jpw84as66u

1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

Toltrazuril Sulfone Standard

1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]phenoxy]phenyl]-

Ponazurilr

Ponazuril ，Toltrazuril sulfone

Veterinary Ponazuril

69004-04-2

9004-04-2

C18H14F3N3O6S

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals