Ponazuril

Product Name: Ponazuril
CAS No.: 69004-04-2
Chemical Name: Ponazuril
Synonyms: 1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H;Ponazuril;Ponazurilr;Unii-jpw84as66u;Ponazuril [inn];ToltrazurilSulfone;C16283700 Ponazuril;Veterinary Ponazuril;Ponazuril in Methanol;Toltrazuril Sulfone Standard
CBNumber: CB01075339
Molecular Formula: C18H14F3N3O6S
Formula Weight: 457.38
MOL File: 69004-04-2.mol

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Ponazuril Property

Melting point:: 242°
Density: 1.507±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 6.46±0.20(Predicted)
form: Solid
color: White to Off-White
InChIKey: VBUNOIXRZNJNAD-UHFFFAOYSA-N
CAS DataBase Reference: 69004-04-2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 33816
Product name: Toltrazuril sulfone
Purity: VETRANAL
Packaging: 10mg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 50mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 250mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29655
Product name: Toltrazuril sulfone
Packaging: 100mg
Price: $169
Updated: 2024/03/01

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Ponazuril Chemical Properties,Usage,Production

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

Uses

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Ponazuril Preparation Products And Raw materials

Raw materials

Preparation Products

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Ponazuril Suppliers

Canada 1 China 127 Germany 2 India 2 Switzerland 1 United Kingdom 1 United States 18 Global 152

LGM Pharma

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BOC Sciences

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Cayman Chemical Company

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MedChemExpress

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Matrix Scientific

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International Laboratory Limited

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View Lastest Price from Ponazuril manufacturers

Sinoway Industrial co., ltd.

Product: Ponazuril ，Toltrazuril sulfone 69004-04-2
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2022-08-25

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ponazuril 69004-04-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-10-27

Hebei Weibang Biotechnology Co., Ltd

Product: Ponazuril 69004-04-2
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-28

69004-04-2, PonazurilRelated Search:

D-Nebivolol,hydrochloride(1:1) Nebivolol Impurity 2 HCl (SR,RS) (+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol Defluoro Nebivolol (Mixture of DiastereoMers) Didefluoro Nebivolol (Mixture of DiastereoMers) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran (-)-Nebivolol Nebivolol Impurity 28 HCl (SS,RS) Nebivolol Impurity 3 Nebivolol Impurity 13 HCl (SS,SS) (2R)-rel-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-benzopyran Toltrazuril 4-(Trifluoromethylthio)phenol 1-Methyl-3-{3-methyl-4-[4-(trifluormethylsulfinyl)-phenoxy]-phenyl}-1,3,5-triazin-2,4,6(1H,3H,5H)-trion 1-METHOXY-4-TRIFLUOROMETHANESULFONYL-BENZENE Ponazuril 1-Methanesulfonyl-4-phenoxy-benzene 1-METHOXY-4-TRIFLUOROMETHYLSULFANYL-BENZENE

Toltrazuril sulfone Ponazuril

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H

Ponazuril

ToltrazurilSulfone

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

Ponazuril [inn]

Unii-jpw84as66u

1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione

Toltrazuril Sulfone Standard

1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1-methyl-3-[3-methyl-4-[4-[(trifluoromethyl)sulfonyl]phenoxy]phenyl]-

Ponazurilr

Ponazuril ，Toltrazuril sulfone

Veterinary Ponazuril

Ponazuril in Methanol

C16283700 Ponazuril

69004-04-2

9004-04-2

C18H14F3N3O6S

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals