2-Amino-5-chlorobenzoic acid

Product Name: 2-Amino-5-chlorobenzoic acid
CAS No.: 635-21-2
Chemical Name: 2-Amino-5-chlorobenzoic acid
Synonyms: 5-CHLOROANTHRANILIC ACID;2-CARBOXY-4-CHLOROANILINE;NSC 404157;2-Amino-5-chL;RARECHEM AL BO 0288;5-Chloranthranilsure;OTAVA-BB BB7020040772;5-Chloro-2-amino acid;Anthranilic acid, 5-chloro-;2-amino-5-chloro-benzoicaci
CBNumber: CB0107619
Molecular Formula: C7H6ClNO2
Formula Weight: 171.58
MOL File: 635-21-2.mol

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2-Amino-5-chlorobenzoic acid Property

Melting point:: 204-206 °C (dec.) (lit.)
Boiling point:: 250°C (rough estimate)
Density: 1.3246 (rough estimate)
refractive index: 1.5560 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.57±0.10(Predicted)
color: White to Pale Grey
Water Solubility: Soluble in water.
BRN: 639027
InChIKey: IFXKXCLVKQVVDI-UHFFFAOYSA-N
CAS DataBase Reference: 635-21-2(CAS DataBase Reference)
NIST Chemistry Reference: Benzoic acid, 2-amino-5-chloro-(635-21-2)
EPA Substance Registry System: Benzoic acid, 2-amino-5-chloro- (635-21-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-37/38-36
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
TSCA: Yes
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 378046
Product name: 2-Amino-5-chlorobenzoic acid
Purity: 90%, technical grade
Packaging: 25g
Price: $77.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: A45475
Product name: 2-Amino-5-chlorobenzoic acid
Purity: 98%
Packaging: 10g
Price: $185
Updated: 2023/06/20

TCI Chemical

Product number: A0665
Product name: 5-Chloroanthranilic Acid
Purity: >99.0%(T)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: A0665
Product name: 5-Chloroanthranilic Acid
Purity: >99.0%(T)
Packaging: 25g
Price: $89
Updated: 2025/07/31

Usbiological

Product number: 006076
Product name: 5-Chloroanthranilic Acid
Packaging: 5g
Price: $319
Updated: 2021/12/16

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2-Amino-5-chlorobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powder

Uses

2-Amino-5-chlorobenzoic acid is used in the preparation of disease-modifying antirheumatic drugs (DMARDs). Also used to produce 6-chloro-3H-quinazolin-4-one at temperature of 180°C.

Uses

2-Amino-5-chlorobenzoic acid is a chlorinated derivative of antharilic acid,it is a metabolite of the pesticide Chlordimeform and it is used in the preparation of disease-modifying antirheumatic drugs (DMARDs).

Uses

5-Chloroanthranilic Acid is a chlorinated derivative of anthranilic acid. 5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. 5-Chloroanthranilic Acid is used in the preparation o f disease-modifying antirheumatic drugs (DMARDs).

Definition

ChEBI: 2-amino-5-chlorobenzoic acid is a member of the class of chlorobenzoic acids that is benzoic acid in which the ring hydrogens at positions 2 and 5 are replaced by amino and chloro groups, respectively. It is an aminobenzoic acid, a member of monochlorobenzenes and a chlorobenzoic acid.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

2516-95-2

635-21-2

General procedure for the synthesis of 2-amino-5-chlorobenzoic acid from 5-chloro-2-nitrobenzoic acid: active Raney nickel (2 g) was added to the reaction flask, followed by the addition of an ethanol solution of 5-chloro-2-nitrobenzoic acid (20 g, 110 mmol). The reaction mixture was stirred at room temperature in a hydrogen atmosphere overnight. Upon completion of the reaction, the reaction solution was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure to give 16 g of white solid product (96% yield). The product was characterized by 1H NMR (DMSO-d6): δ 6.77 (d, J = 8.9 Hz, 1H), 7.24 (dd, J = 2.9, 8.9 Hz, 1H), 7.62 (d, J = 2.9 Hz, 1H), 8.7 (br, 3H); EIMS: 170 (M-H).

References

[1] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109
[2] Patent: WO2004/74218, 2004, A2. Location in patent: Page 115-116
[3] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 12, p. 2801 - 2809
[4] Chemical Biology and Drug Design, 2016, p. 710 - 723
[5] Zhurnal Obshchei Khimii, 1938, vol. 8, p. 1797,1801

2-Amino-5-chlorobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-Chlorobenzoic acid 5-Chloro-2-fluorobenzoic acid

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2-Amino-5-chlorobenzoic acid Suppliers

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View Lastest Price from 2-Amino-5-chlorobenzoic acid manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 2-Amino-5-chlorobenzoic acid 635-21-2
Price: US $5.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Amino-5-chlorobenzoic acid 635-21-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-04

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-5-chlorobenzoic acid 635-21-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

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5-Chloranthranilsure

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635-21-2

Peptide Synthesis

Unnatural Amino Acid Derivatives

Specialty Synthesis

Aromatic Amino Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

Organic acids

Acids & Esters

Anilines, Amides & Amines

Chlorine Compounds

amine| carboxylic acid| alkyl chloride

Aromatics, Intermediates, Metabolites & Impurities

API Intermediate

Amino Acids and Derivatives

Aromatics

Intermediates

Metabolites & Impurities

FINE Chemical & INTERMEDIATES