6-Chloro-imidazo[1,2-a]pyrazine
Uses- Product Name
- 6-Chloro-imidazo[1,2-a]pyrazine
- CAS No.
- 76537-23-0
- Chemical Name
- 6-Chloro-imidazo[1,2-a]pyrazine
- Synonyms
- 6-Chloro-imidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 6-chloro-
- CBNumber
- CB01113381
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 76537-23-0.mol
6-Chloro-imidazo[1,2-a]pyrazine Property
- Melting point:
- 137-138℃
- Density
- 1.51
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.68±0.30(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C381690
- Product name
- 6-Chloroimidazo[1,2-a]pyrazine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C12875
- Product name
- 6-Chloroimidazo[1,2-a]pyrazine
- Purity
- 95%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 3H32-5-J0
- Product name
- 6-Chloroimidazo[1,2-a]pyrazine
- Packaging
- 250mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- 3H32-5-J0
- Product name
- 6-Chloroimidazo[1,2-a]pyrazine
- Packaging
- 5G
- Price
- $576
- Updated
- 2021/12/16
- Product number
- W8334
- Product name
- 6-Chloroimidazo[1,2-a]pyrazine
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
6-Chloro-imidazo[1,2-a]pyrazine Chemical Properties,Usage,Production
Uses
6-Chloroimidazole[1,2A]pyrazine is a heterocyclic derivative that can be used as a pharmaceutical intermediate.
Synthesis
33332-29-5
2032-35-1
76537-23-0
2-Amino-5-chloropyrazine (2.6 g, 20 mmol) and 2-bromo-1,1-diethoxyethane (12.0 g, 60.89 mmol) were used as starting materials and dissolved in 30 mL of isopropanol. Subsequently, hydrogen bromide solution (10.5 g, 62.22 mmol) was added to the reaction system and the reaction was stirred at 80°C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with sodium bicarbonate to 8. Next, extraction was carried out with dichloromethane, the organic phases were separated and combined, and the crude product was concentrated under reduced pressure. Purification by Combi-flash fast column chromatography (eluent ratio: dichloromethane:methanol = 90:10:70:30) afforded a brown solid product, 6-chloroimidazo[1,2A]pyrazine (2.3 g), in a yield of 49.75% and a purity of 96.63%. The product did not need further purification and could be used directly in the subsequent reaction.
References
[1] Patent: CN105524068, 2016, A. Location in patent: Paragraph 0286; 0287
[2] Journal of Medicinal Chemistry, 1983, vol. 26, # 3, p. 357 - 363
6-Chloro-imidazo[1,2-a]pyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Chloro-imidazo[1,2-a]pyrazine Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
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- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from 6-Chloro-imidazo[1,2-a]pyrazine manufacturers
- Product
- 6-Chloro-imidazo[1,2-a]pyrazine 76537-23-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%minNMR
- Supply Ability
- 50kg/month
- Release date
- 2022-05-10