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Euphorbiasteroid

Product Name
Euphorbiasteroid
CAS No.
28649-59-4
Chemical Name
Euphorbiasteroid
Synonyms
Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid(EuphorbiaFactor L1);6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
CBNumber
CB01118210
Molecular Formula
C32H40O8
Formula Weight
552.66
MOL File
28649-59-4.mol
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Euphorbiasteroid Property

Melting point:
199~200℃
Boiling point:
633.1±55.0 °C(Predicted)
Density 
1.23
storage temp. 
4°C, protect from light
solubility 
DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
form 
A crystalline solid
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Safety

Safety Statements 
24/25
HS Code 
29061990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
25mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
250mg
Price
$961
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
50mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
100mg
Price
$411
Updated
2024/03/01
TRC
Product number
E938885
Product name
Euphorbiasteroid
Packaging
5mg
Price
$55
Updated
2021/12/16
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Euphorbiasteroid Chemical Properties,Usage,Production

Uses

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Preparation Products And Raw materials

Raw materials

Preparation Products

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Euphorbiasteroid Suppliers

Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai Zhanshu Chemical Technology Co., Ltd
Tel
+86-21-58589556
Fax
+86-21-58589557
Country
China
ProdList
413
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773
Fax
021-61486878
Email
sales@aspirebio.com
Country
China
ProdList
2880
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
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View Lastest Price from Euphorbiasteroid manufacturers

Hebei Fengjia New Material Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-08
Hebei Weibang Biotechnology Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-07-12
Hebei Mojin Biotechnology Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30

28649-59-4, EuphorbiasteroidRelated Search:


  • Daughter son sterol
  • 6,20-Epoxylathyrol phenylacetate diacetate
  • Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Euphorbia factor L1
  • Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...
  • Euphorbiasteroid(EuphorbiaFactor L1)
  • (1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate
  • 28649-59-4
  • 32H40O8
  • C32H40O8