Euphorbiasteroid
- Product Name
- Euphorbiasteroid
- CAS No.
- 28649-59-4
- Chemical Name
- Euphorbiasteroid
- Synonyms
- Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid(EuphorbiaFactor L1);6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
- CBNumber
- CB01118210
- Molecular Formula
- C32H40O8
- Formula Weight
- 552.66
- MOL File
- 28649-59-4.mol
Euphorbiasteroid Property
- Melting point:
- 199~200℃
- Boiling point:
- 633.1±55.0 °C(Predicted)
- Density
- 1.23
- storage temp.
- 4°C, protect from light
- solubility
- DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM) - form
- A crystalline solid
Safety
- Safety Statements
- 24/25
- HS Code
- 29061990
N-Bromosuccinimide Price
- Product number
- 27822
- Product name
- Euphorbiasteroid
- Packaging
- 25mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 27822
- Product name
- Euphorbiasteroid
- Packaging
- 250mg
- Price
- $961
- Updated
- 2024/03/01
- Product number
- 27822
- Product name
- Euphorbiasteroid
- Packaging
- 50mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 27822
- Product name
- Euphorbiasteroid
- Packaging
- 100mg
- Price
- $411
- Updated
- 2024/03/01
- Product number
- E938885
- Product name
- Euphorbiasteroid
- Packaging
- 5mg
- Price
- $55
- Updated
- 2021/12/16
Euphorbiasteroid Chemical Properties,Usage,Production
Uses
Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.
Biological Functions
Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.
Euphorbiasteroid Preparation Products And Raw materials
Raw materials
Preparation Products
Euphorbiasteroid Suppliers
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View Lastest Price from Euphorbiasteroid manufacturers
- Product
- Euphorbiasteroid 28649-59-4
- Price
- US $9.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- Euphorbiasteroid 28649-59-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-07-12
- Product
- Euphorbiasteroid 28649-59-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-30