Euphorbiasteroid

Product Name: Euphorbiasteroid
CAS No.: 28649-59-4
Chemical Name: Euphorbiasteroid
Synonyms: Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid（EuphorbiaFactor L1）;6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
CBNumber: CB01118210
Molecular Formula: C32H40O8
Formula Weight: 552.66
MOL File: 28649-59-4.mol

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Euphorbiasteroid Property

Melting point:: 199～200℃
Boiling point:: 633.1±55.0 °C(Predicted)
Density: 1.23
storage temp.: 4°C, protect from light
solubility: DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
form: A crystalline solid

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Safety

Safety Statements: 24/25
HS Code: 29061990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27822
Product name: Euphorbiasteroid
Packaging: 25mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 27822
Product name: Euphorbiasteroid
Packaging: 250mg
Price: $961
Updated: 2024/03/01

Cayman Chemical

Product number: 27822
Product name: Euphorbiasteroid
Packaging: 50mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 27822
Product name: Euphorbiasteroid
Packaging: 100mg
Price: $411
Updated: 2024/03/01

TRC

Product number: E938885
Product name: Euphorbiasteroid
Packaging: 5mg
Price: $55
Updated: 2021/12/16

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Euphorbiasteroid Chemical Properties,Usage,Production

Uses

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Preparation Products And Raw materials

Raw materials

Preparation Products

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Euphorbiasteroid Suppliers

China 109 Germany 1 India 1 United Kingdom 1 United States 11 Global 123

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
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ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4941
Advantage: 60

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
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Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-1865138 13341702378
Fax: QQ：190129269
Email: 190129269@qq.com
Country: China
ProdList: 1010
Advantage: 58

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
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Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
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Shanghai Zhanshu Chemical Technology Co., Ltd

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Fax: +86-21-58589557
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Shanghai JONLN Reagent Co., Ltd.

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ProdList: 9986
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
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Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2881
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View Lastest Price from Euphorbiasteroid manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: Euphorbiasteroid 28649-59-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

Shanghai Standard Technology Co., Ltd.

Product: Euphobiasteroid 28649-59-4
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-23

Hebei Guanlang Biotechnology Co., Ltd.

Product: Euphorbiasteroid 28649-59-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-07-12

28649-59-4, EuphorbiasteroidRelated Search:

Euphorbia factor L7b beta-Sitosterol Dodecanoic acid ingenol ester Ingenol mebutate 17-Hydroxyisolathyrol 20-DEOXYINGENOL (6R)-6,6aβ,7aβ,8,9,12,12a,12bβ-Octahydro-12α,12aα-dihydroxy-2,2,7,7,9β,11-hexamethyl-7H-6β,9aβ-methano-4H-cyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d]-1,3-dioxin-13-one Euphorbia factor L1 euphorbiafactor L2 DIACETYL BENZOYL LATHYROL Ingenol (1aR,7bR)-1aα,2,7aα,13,14,14aα-Hexahydro-1,1,6,6,9,9,11,13α-octamethyl-10aαH-2α,12aα-methano-1H,4H-cyclopropa[5,6][1,3]dioxolo[2',3']cyclopenta[1',2':9,10]cyclodeca[1,2-d][1,3]dioxin-15-one Euphorbiasteroid TRANS-CYCLODODECENE

Daughter son sterol

6,20-Epoxylathyrol phenylacetate diacetate

Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester

Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester

Euphorbia factor L1

Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees

(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate

(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...

Euphorbiasteroid（EuphorbiaFactor L1）

28649-59-4

32H40O8

C32H40O8