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Euphorbiasteroid

Product Name
Euphorbiasteroid
CAS No.
28649-59-4
Chemical Name
Euphorbiasteroid
Synonyms
Euphorbia factor L1;Daughter son sterol;Euphorbiasteroid（EuphorbiaFactor L1）;6,20-Epoxylathyrol phenylacetate diacetate;Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...;Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester;(1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate;(1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate;Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
CBNumber
CB01118210
Molecular Formula
C32H40O8
Formula Weight
552.66
MOL File
28649-59-4.mol
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Euphorbiasteroid Property

Melting point:
199～200℃
Boiling point:
633.1±55.0 °C(Predicted)
Density 
1.23
storage temp. 
4°C, protect from light
solubility 
DMSO:15.0(Max Conc. mg/mL);27.14(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.05(Max Conc. mM)
form 
A crystalline solid
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Safety

Safety Statements 
24/25
HS Code 
29061990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
25mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
250mg
Price
$961
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
50mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
27822
Product name
Euphorbiasteroid
Packaging
100mg
Price
$411
Updated
2024/03/01
TRC
Product number
E938885
Product name
Euphorbiasteroid
Packaging
5mg
Price
$55
Updated
2021/12/16
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Euphorbiasteroid Chemical Properties,Usage,Production

Uses

Euphorbiasteroid is a compound used to induce HL-60 cells to apoptosis via promoting Bcl/Bax apoptotic signaling pathway in a dose-dependent manner.

Biological Functions

Euphorbiasteroid, Euphorbia Factor L1 (EFL1) to be specific, with a tricyclic terpenoid skeleton, consisting of fused five-, eleven- and three-membered rings, is a diterpenoid isolated from the seeds of Euhporbia lathyris L. It is reported EFL1 could be helpful to reduces the expression of Bcl-2, PI3K, AKT and mTOR protein and mRNA, upregulates cleaved caspase-9 and caspase-3 levels, but shows no effect on pro-caspase-9 and pro-caspase-3. EFL1 also could induce apoptosis, and possess anticancer, antiadipogenesis, antiosteoclastogenesis and multi-drug resistance-modulating effect.
Euphorbiasteroid showed effects on adipogenesis of 3T3-L1 pre-adipocytes. Euphorbiasteroid also has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5.EFL1 inhibited osteoclastogenesis and induced osteoclast apoptosis. Euphorbiasteroid suppressed osteoclast formation and bone resorption at both initial and terminal differentiation stages.

Euphorbiasteroid Preparation Products And Raw materials

Raw materials

Preparation Products

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Euphorbiasteroid Suppliers

China 116 Germany 1 India 1 United Kingdom 1 United States 11 Global 130
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View Lastest Price from Euphorbiasteroid manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
Hebei Fengjia New Material Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2024-08-08
Hebei Mojin Biotechnology Co., Ltd
Product
Euphorbiasteroid 28649-59-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30

28649-59-4, EuphorbiasteroidRelated Search:

Euphorbia factor L7b beta-Sitosterol Dodecanoic acid ingenol ester Ingenol mebutate 17-Hydroxyisolathyrol 20-DEOXYINGENOL (6R)-6,6aβ,7aβ,8,9,12,12a,12bβ-Octahydro-12α,12aα-dihydroxy-2,2,7,7,9β,11-hexamethyl-7H-6β,9aβ-methano-4H-cyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d]-1,3-dioxin-13-one Euphorbia factor L1 euphorbiafactor L2 DIACETYL BENZOYL LATHYROL Ingenol (1aR,7bR)-1aα,2,7aα,13,14,14aα-Hexahydro-1,1,6,6,9,9,11,13α-octamethyl-10aαH-2α,12aα-methano-1H,4H-cyclopropa[5,6][1,3]dioxolo[2',3']cyclopenta[1',2':9,10]cyclodeca[1,2-d][1,3]dioxin-15-one Euphorbiasteroid TRANS-CYCLODODECENE

  • Daughter son sterol
  • 6,20-Epoxylathyrol phenylacetate diacetate
  • Benzeneacetic acid (1aR,2'R,2E,4aR,6S,7S,7aR,8S,11aS)-4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Benzeneacetic acid 4a,8-bis(acetyloxy)-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-4-oxospiro[9H-cyclopenta[a]cyclopropa[f]cycloundecene-9,2'-oxiran]-7-yl ester
  • Euphorbia factor L1
  • Euphorbiasteroid, 98%, from Leptochloa chinensis (L.) Nees
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,6-tetramethyl-4-oxo-1,1a,4,4a,5,6,7,7a,8,10,11,11a-dodecahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-7-yl phenylacetate
  • (1aS,2E,4aR,6S,7S,7aS,8S,9R,11aS)-4a,8-bis(acetyloxy)-1,1,3,...
  • Euphorbiasteroid（EuphorbiaFactor L1）
  • (1aR,4aR,6S,7S,7aR,8S,9R,11aS,E)-1,1,3,6-Tetramethyl-4-oxo-7-(2-phenylacetoxy)-1,1a,4,6,7,7a,8,10,11,11a-decahydrospiro[cyclopenta[a]cyclopropa[f][11]annulene-9,2'-oxiran]-4a,8(5H)-diyl diacetate
  • 28649-59-4
  • 32H40O8
  • C32H40O8