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Micafungin sodium

Product Name
Micafungin sodium
CAS No.
208538-73-2
Chemical Name
Micafungin sodium
Synonyms
CS-705;Funguard;Mycamine;FK463 Sodium;Mycamine Sodium;Caffeine sodium;Micafungin sodium;Micafungin Sodium Salt;Micafungin sodium, >=98%;micafungin sodium Impurity
CBNumber
CB01120439
Molecular Formula
C56H72N9NaO23S
Formula Weight
1294.28
MOL File
208538-73-2.mol
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Micafungin sodium Property

Melting point:
>180°C (dec.)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
208538-73-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18009
Product name
Micafungin (sodium salt)
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18009
Product name
Micafungin (sodium salt)
Purity
≥95%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18009
Product name
Micafungin (sodium salt)
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
18009
Product name
Micafungin (sodium salt)
Purity
≥95%
Packaging
25mg
Price
$381
Updated
2024/03/01
TRC
Product number
M342350
Product name
MicafunginSodium
Packaging
25mg
Price
$595
Updated
2021/12/16
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Micafungin sodium Chemical Properties,Usage,Production

Description

The semi-synthetic echinocandin antifungal agent, micafungin sodium (15), is a 1,3-β-glucan synthase inhibitor discovered by Fujisawa. It is for the treatment and prevention of infections caused by Aspergillus and Candida such as fungemia, respiratory mycosis and gastrointestinal mycosis.

Chemical Properties

Off-White Solid

Uses

An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.

Uses

Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]

Uses

Micafungin sodium is the salt of the semi-synthetic cyclic lipopeptide, micafungin, a member of the echinocandin class that was reported in 1999 from Fujisawa in Japan. The sodium salt takes advantage of the aryl sulphate moiety providing improved water solubility and is the preferred salt for pharmaceutical applications. Like all echinocandins, micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.

brand name

Mycamine(Astellas).

Synthesis

The key intermediate for the side chain of micafungin (15) was prepared by regioselective 1,3-dipolar cycloaddition reaction of 4-methoxycarbonylbenzhydroxamic acid chloride (147) and 4-pentyloxyphenylacetylene (148) with TEA in THF. Basic hydrolysis of thus obtained ester 149 , followed by condensation with 1- hydroxybenzotriazole (HOBT) gave the corresponding activated ester 150 in 95% yield. The cyclic peptide core 151, obtained by acylase-catalyzed hydrolysis of the natural product FR901379, was acylated with 150 to give micafungin (15) in 53% yield.

Micafungin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Micafungin sodium manufacturers

ANHUI WITOP BIOTECH CO., LTD
Product
Micafungin sodium 208538-73-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10 tons
Release date
2021-03-19
Shaanxi Dideu Medichem Co. Ltd
Product
Micafungin sodium 208538-73-2
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Wuhan Boyuan Import & Export Co., LTD
Product
Micafungin Sodium Impurity 208538-73-2
Price
US $10.00-17.00/kg
Min. Order
10kg
Purity
99％
Supply Ability
1000
Release date
2023-02-10

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  • Micafungin sodium
  • 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandin A0 MonosodiuM Salt
  • Funguard
  • Micafungin SodiuM(FK-463, MycaMine)
  • Mycamine
  • CS-705
  • FK 463; FUNGUARD; MYCAMINE
  • micafungin sodium Impurity
  • Micafungin Sodium Salt
  • FK463 Sodium
  • Micafungin sodium Mycamine
  • Micafungin sodium, >=98%
  • Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1)
  • Micafungin Sodium (FK 463)
  • Mycamine Sodium
  • Micafungin sodium USP/EP/BP
  • Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate
  • Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12
  • US-DMF No.: 031449 ASMF Approved
  • Micafungin SodiumQ: What is Micafungin Sodium Q: What is the CAS Number of Micafungin Sodium Q: What is the storage condition of Micafungin Sodium
  • Micafungin-D11 Sodium salt
  • 208538-73-2 Micafungin sodium
  • Caffeine sodium
  • Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate[FK 463 Sodium
  • Micafungin Sodium (200 mg) (INTERNATIONAL COLD SHIPMENT REQUIRED)
  • Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate
  • 208538-73-2
  • C56H70N9NaO23S
  • C56H70N9O23SNa
  • Inhibitors
  • API