Micafungin sodium

Product Name: Micafungin sodium
CAS No.: 208538-73-2
Chemical Name: Micafungin sodium
Synonyms: CS-705;Funguard;Mycamine;FK463 Sodium;Mycamine Sodium;Caffeine sodium;Micafungin sodium;Micafungin Sodium Salt;Micafungin sodium, >=98%;micafungin sodium Impurity
CBNumber: CB01120439
Molecular Formula: C56H72N9NaO23S
Formula Weight: 1294.28
MOL File: 208538-73-2.mol

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Micafungin sodium Property

Melting point:: >180°C (dec.)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 208538-73-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18009
Product name: Micafungin (sodium salt)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18009
Product name: Micafungin (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18009
Product name: Micafungin (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 18009
Product name: Micafungin (sodium salt)
Purity: ≥95%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

TRC

Product number: M342350
Product name: MicafunginSodium
Packaging: 10mg
Price: $325
Updated: 2021/12/16

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Micafungin sodium Chemical Properties,Usage,Production

Description

The semi-synthetic echinocandin antifungal agent, micafungin sodium (15), is a 1,3-β-glucan synthase inhibitor discovered by Fujisawa. It is for the treatment and prevention of infections caused by Aspergillus and Candida such as fungemia, respiratory mycosis and gastrointestinal mycosis.

Chemical Properties

Off-White Solid

Uses

An echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, and represent a valuable treatment option for fungal infections.

Uses

Micafungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthesis. It has fungicidal activity against virtually all species of Candida, including those resistant to fluconazole, and is fungistatic against Aspergillus spp.[Cayman Chemical]

Uses

Micafungin sodium is the salt of the semi-synthetic cyclic lipopeptide, micafungin, a member of the echinocandin class that was reported in 1999 from Fujisawa in Japan. The sodium salt takes advantage of the aryl sulphate moiety providing improved water solubility and is the preferred salt for pharmaceutical applications. Like all echinocandins, micafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: Micafungin sodium is an organic sodium salt and an antibiotic antifungal drug.

brand name

Mycamine(Astellas).

Synthesis

The key intermediate for the side chain of micafungin (15) was prepared by regioselective 1,3-dipolar cycloaddition reaction of 4-methoxycarbonylbenzhydroxamic acid chloride (147) and 4-pentyloxyphenylacetylene (148) with TEA in THF. Basic hydrolysis of thus obtained ester 149 , followed by condensation with 1- hydroxybenzotriazole (HOBT) gave the corresponding activated ester 150 in 95% yield. The cyclic peptide core 151, obtained by acylase-catalyzed hydrolysis of the natural product FR901379, was acylated with 150 to give micafungin (15) in 53% yield.

Micafungin sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Micafungin sodium Suppliers

Canada 1 China 237 India 10 Israel 1 South Korea 1 Spain 1 United Kingdom 1 United States 14 Global 266

Sumar Biotech Llp

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Triveni Interchem Private Limited (Group Of Triveni...

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SynZeal Research Pvt Ltd

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Pharmaffiliates Analytics and Synthetics P. Ltd

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BIOCON LTD

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View Lastest Price from Micafungin sodium manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Micafungin Sodium Impurity 208538-73-2
Price: US $10.00-17.00/kg
Min. Order: 10kg
Purity: 99％
Supply Ability: 1000
Release date: 2023-02-10

ANHUI WITOP BIOTECH CO., LTD

Product: Micafungin sodium 208538-73-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10 tons
Release date: 2021-03-19

Shaanxi Dideu Medichem Co. Ltd

Product: Micafungin sodium 208538-73-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

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Micafungin sodium

1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneuMocandin A0 MonosodiuM Salt

Funguard

Micafungin SodiuM(FK-463, MycaMine)

Mycamine

CS-705

FK 463; FUNGUARD; MYCAMINE

micafungin sodium Impurity

Micafungin Sodium Salt

FK463 Sodium

Micafungin sodium Mycamine

Micafungin sodium, >=98%

Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]-, sodium salt (1:1)

Micafungin Sodium (FK 463)

Mycamine Sodium

Micafungin sodium USP/EP/BP

Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate

Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12

US-DMF No.: 031449 ASMF Approved

Micafungin SodiumQ: What is Micafungin Sodium Q: What is the CAS Number of Micafungin Sodium Q: What is the storage condition of Micafungin Sodium

Micafungin-D11 Sodium salt

208538-73-2 Micafungin sodium

Caffeine sodium

Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate[FK 463 Sodium

Micafungin Sodium (200 mg) (INTERNATIONAL COLD SHIPMENT REQUIRED)

Sodium 5-((1S,2S)-2-((2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxy-3-oxopropyl)-2,8,11,12,14,15,22,25-octahydroxy-6-((R)-1-hydroxyethyl)-16-methyl-5,19-dioxo-9-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzamido)-2,3,5,6,9,10,11,12,14a,15,16,17,19,20,23,25a-hexadecahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl)-1,2-dihydroxyethyl)-2-hydroxyphenyl sulfate

208538-73-2

C56H70N9NaO23S

C56H70N9O23SNa

Inhibitors

API