Losartan Carboxaldehyde

Product Name: Losartan Carboxaldehyde
CAS No.: 114798-36-6
Chemical Name: Losartan Carboxaldehyde
Synonyms: DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan Potassium Impurity K;Losartan USP Related Compound C
CBNumber: CB01176401
Molecular Formula: C22H21ClN6O
Formula Weight: 420.89
MOL File: 114798-36-6.mol

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Losartan Carboxaldehyde Property

Melting point:: 84-86°C
Boiling point:: 666.7±65.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, Under Inert Atmosphere
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 4.16±0.10(Predicted)
color: Off-White to Light Yellow
CAS DataBase Reference: 114798-36-6

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Safety

HS Code: 2933290000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18855
Product name: Losartan Carboxaldehyde
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 18855
Product name: Losartan Carboxaldehyde
Purity: ≥95%
Packaging: 5mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 18855
Product name: Losartan Carboxaldehyde
Purity: ≥95%
Packaging: 10mg
Price: $249
Updated: 2024/03/01

TRC

Product number: L470505
Product name: LosartanCarboxaldehyde
Packaging: 50mg
Price: $670
Updated: 2021/12/16

Usbiological

Product number: 281287
Product name: Losartan carboxaldehyde
Packaging: 2mg
Price: $345
Updated: 2021/12/16

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Losartan Carboxaldehyde Chemical Properties,Usage,Production

Description

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A₂ and prostaglandin F_2α . Losartan carboxaldehyde can also act as a partial agonist (EC₅₀ = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

Chemical Properties

Yellow Solid

Uses

A metabolite of Losartan. An intermediate in the synthesis of the EXP 3174

Uses

A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan

Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

in vitro

losartan is an intermediate aldehyde metabolite of losartan, the angiotensin ii type 1 receptor antagonist. losartan could not block angiotensin receptors, but inhibit the expression of endothelial cyclooxygenase (cox)-2, therefore exerting anti-inflammatory actions. moreover, losartan at 1 μm was able to block the upregulation of icam-1 mrna and cox-dependent generation of thromboxane a2 and prostaglandin f2α [1].

in vivo

in animal stufdy, losartan was infused for 10 days to rats on a normal sodium intake (nna) and rats on a high sodium intake (hna) to suppress endogenous ang ii. although basal plasma renin activity was markedly suppressed in hna rats compared with nna rats, control arterial pressure was not different between nna and hna rats. losartan could decrease arterial pressure from control levels in nna rats on the first day of infusion but had no effect on arterial pressure in hna rats. in addition, by day 10 of losartan infusion, arterial pressure had decreased further from control levels in nna rats but remained unchanged compared with control in hna rats [2].

References

[1] c. kr mer, j. sunkomat, j. witte, et al. angiotensin ii receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite exp3179. circulation research 90(7), 770-776 (2002).
[2] collister jp, hornfeldt bj, osborn jw. hypotensive response to losartan in normal rats. role of ang ii and the area postrema. hypertension. 1996 mar;27(3 pt 2):598-606.
[3] goa kl, wagstaff aj. losartan potassium: a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension. drugs. 1996 may;51(5):820-45.

Losartan Carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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Losartan Carboxaldehyde Suppliers

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View Lastest Price from Losartan Carboxaldehyde manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Allisartan Isoproxil Impurity 14 114798-36-6
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-01

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Allisartan Isoproxil Impurity 14 114798-36-6
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-01

114798-36-6, Losartan CarboxaldehydeRelated Search:

Losartan carboxylic acid N2-Losartanyl-losartan (Losartan IMpurity) Losartan IsoMer IMpurity, PotassiuM Salt 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol N1-Losartanyl-losartan (Losartan IMpurity) Triphenylmethanol 2-Butyl-4-chloro-5-formylimidazole Losartan Impurity D 5-(4'-((2-butyl-4-chloro-5-(isopropoxymethyl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Losartan IMpurity C (Isolosartan) O-Acetyl Losartan Losartan potassium Losartan Losartan Carboxaldehyde AKOS 91711 AKOS 91707

2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

DUP 167

EXP 3179

Losartan CarboxaldehydeDiscontinued see product # L470505

Losartan Carboxaldehyde

2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

Losartan Carboxaldehyde-d3

Losartan EP Impurity K (Losartan Carboxaldehyde)

2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde

Losartan EP IMpurity K (LosaratnCarboxaldehyde)

Losartan EP IMpurity K

Losartan Related CoMpound C

Losartan Aldehyde

1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

Losartan Impurity K (EP)

2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde

Losartan Impurity 11(Losartan EP Impurity K)

Losartan EP Impurity K:Losartan Impurity K

1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Allisartan Isoproxil impurity II

Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde)

Losartan Carboxaldehyde_x000b_Discontinued see product # L470505

Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495)

Losartan USP Related Compound C

DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167

Losartan Potassium EP Impurity K

Losartan Potassium Impurity K

1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde

Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde)

Losartan EP Impurity K Losartan USP RC C

114798-36-6

14798-36-6

C22H21ClN6O

Intermediates & Fine Chemicals

Isotope Labelled Compounds

Metabolites & Impurities

Pharmaceuticals

Isotope Labeled Compounds