Brequinar

Product Name: Brequinar
CAS No.: 96187-53-0
Chemical Name: Brequinar
Synonyms: BPQ;CS-157;Brequinar;Biphenquinate;Brequinar (DUP785);BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.;6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl);6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl;6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci
CBNumber: CB01178142
Molecular Formula: C23H15F2NO2
Formula Weight: 375.37
MOL File: 96187-53-0.mol

More

Less

Brequinar Property

Melting point:: 355-357℃ (N,N-dimethylformamide water )
storage temp.: 2-8°C
solubility: DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM)
form: powder to crystal
pka: pKa 4.45(H2O t=RT I=0.10) (Uncertain)
color: White to Light yellow
CAS DataBase Reference: 96187-53-0

More

Less

Safety

HS Code: 2933.49.7000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $161
Updated: 2024/03/01

TCI Chemical

Product number: B5707
Product name: Brequinar
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $531
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 24445
Product name: Brequinar
Purity: ≥98%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

More

Less

Brequinar Chemical Properties,Usage,Production

Uses

Antineoplastic.

Definition

ChEBI: Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-).

Brequinar Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Brequinar Suppliers

Americas 1 CHINA 78 Europe 1 India 3 Japan 1 United Kingdom 1 United States 14 Global 99

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

RIA International LLC

Tel: --
Fax: --
Email: marketing@riausa.net
Country: United States
ProdList: 1324
Advantage: 50

96187-53-0, BrequinarRelated Search:

Quinapril SODIUM 4-PYRIDINECARBOXYLATE TETRAHYDRATE 3-METHYLQUINOLINE-4-CARBOXYLIC ACID 6-Fluoroquinaldine 3-METHYL-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID Brequinar 4-METHYL-2-P-TOLYL-PYRIDINE 2-P-TOLYL-QUINOLINE-4-CARBOXYLIC ACID 6-FLUORO-2-METHYLQUINOLINE-4-CARBOXYLIC ACID 2-BIPHENYL-4-YL-QUINOLINE-4-CARBOXYLIC ACID

Brequinar

6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid

6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl

4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl-

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

Biphenquinate

BPQ

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)

Brequinar (DUP785)

BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid

CS-157

NSC-368390,DHODH,Inhibitor,DUP 785,Brequinar,Virus Protease,Dihydroorotate Dehydrogenase,DNA/RNA Synthesis,SARS coronavirus,inhibit,DUP-785,SARS-CoV,NSC368390

6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylicaci

6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid

96187-53-0

C22H13F2NO2

C23H15F2NO2

API