Declopramide
- Product Name
- Declopramide
- CAS No.
- 891-60-1
- Chemical Name
- Declopramide
- Synonyms
- IMO-B;OXI-104;Declopramide;3-Chloroprocainamide;4-amino-3-chloro-N-(2-diethylaminoethyl)benzamide;4-azanyl-3-chloro-N-(2-diethylaminoethyl)benzamide;Benzamide, 4-amino-3-chloro-N-[2-(diethylamino)ethyl]-
- CBNumber
- CB01178430
- Molecular Formula
- C13H20ClN3O
- Formula Weight
- 269.77
- MOL File
- 891-60-1.mol
Declopramide Property
- Boiling point:
- 404.2±45.0 °C(Predicted)
- Density
- 1.153±0.06 g/cm3(Predicted)
- pka
- 13.76±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- 4238CA
- Product name
- Declopramide
- Packaging
- 100mg
- Price
- $453
- Updated
- 2021/12/16
- Product number
- API0014462
- Product name
- DECLOPRAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.3
- Updated
- 2021/12/16
- Product number
- 4238CA
- Product name
- Declopramide
- Packaging
- 250mg
- Price
- $604
- Updated
- 2021/12/16
Declopramide Chemical Properties,Usage,Production
Uses
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research[1][2][3].
References
[1] Hua J, et al., Comparison of antitumor activity of declopramide (3-chloroprocainamide) and N-acetyl-declopramide. Anticancer Res. 1999 Jan-Feb;19(1A):285-90. PMID:10226556
[2] Hua J, et al., Pharmacokinetics and central nervous system toxicity of declopramide (3-chloroprocainamide) in rats and mice. Anticancer Drugs. 1999 Jan;10(1):79-88. DOI:10.1097/00001813-199901000-00010
[3] Lindgren H, et al., Differential usage of IkappaBalpha and IkappaBbeta in regulation of apoptosis versus gene expression. Biochem Biophys Res Commun. 2003 Jan 31;301(1):204-11. DOI:10.1016/s0006-291x(02)03012-7