PHT-GLY-OTBU
- Product Name
- PHT-GLY-OTBU
- CAS No.
- 6297-93-4
- Chemical Name
- PHT-GLY-OTBU
- Synonyms
- NSC126801;PHT-GLY-OTBU;Pht-Gly-OtBu-OH;Pht-Gly-OtBu 98%;Phthaloyl-glycinetertutylester;PHTHALYL-GLYCINE T-BUTYL ESTER;PHTHALOYL-GLYCINE T-BUTYL ESTER;Phthaloyl-glycine tert·butyl ester;N-PHTHALOYLGLYCINE TERT.-BUTYL ESTER;tert-butyl 2-(1,3-dioxoisoindol-2-yl)acetate
- CBNumber
- CB0119353
- Molecular Formula
- C14H15NO4
- Formula Weight
- 261.27
- MOL File
- 6297-93-4.mol
PHT-GLY-OTBU Property
- Melting point:
- 96.0-97.5 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
- Boiling point:
- 370.8±25.0 °C(Predicted)
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.49±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- S671657
- Product name
- N-PHTHALOYLGLYCINE TERT.-BUTYL ESTER
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S671657
- Product name
- N-PHTHALOYLGLYCINE TERT.-BUTYL ESTER
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 9825AJ
- Product name
- Pht-Gly-Otbu
- Packaging
- 1g
- Price
- $181
- Updated
- 2021/12/16
- Product number
- 9825AJ
- Product name
- Pht-Gly-Otbu
- Packaging
- 5g
- Price
- $443
- Updated
- 2021/12/16
- Product number
- 9825AJ
- Product name
- Pht-Gly-Otbu
- Packaging
- 10g
- Price
- $639
- Updated
- 2021/12/16
PHT-GLY-OTBU Chemical Properties,Usage,Production
Synthesis
5292-43-3
1074-82-4
6297-93-4
A 250 mL three-necked flask was equipped with a thermocouple, nitrogen inlet tube and magnetic stirrer and tert-butyl bromoacetate (10 g, 51 mmol) was added. Subsequently, acetone (100 mL) was added as a solvent and tetrabutylammonium bromide (0.8 g, 2.5 mmol) was added as a phase transfer catalyst. The potassium salt of phthalimide was added all at once and the reaction system was heated to 45 °C and maintained for 15 hours. Upon completion of the reaction, the mixture was cooled to 21 °C and concentrated by rotary evaporator to remove acetone. Ethyl acetate (100 mL) and water (30 mL) were added to the concentrate and stirred at 21 °C for 20 min to achieve phase separation. The organic layer was separated and washed sequentially with saturated sodium carbonate solution (3 x 30 mL) and brine. The organic phase was concentrated to remove volatile solvents. The crude product was suspended in ethanol (30 mL) and water (30 mL) was added slowly for 30 minutes. The suspension was stirred overnight at 21 °C, followed by collection of the solid product by filtration and washing with water to give the final tert-butyl 2-(1,3-dioxoisoindolin-2-yl)acetate in 78.4% isolated yield and 99.29% HPLC purity.
References
[1] Heterocycles, 2010, vol. 80, # 2, p. 989 - 1002
[2] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 23, p. 6209 - 6217
PHT-GLY-OTBU Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PHT-GLY-OTBU manufacturers
- Product
- Pht-Gly-OtBu 6297-93-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98% 99+
- Supply Ability
- 1T+
- Release date
- 2024-07-18