N-(2-Hydroxyethyl)phthalimide

Product Name: N-(2-Hydroxyethyl)phthalimide
CAS No.: 3891-07-4
Chemical Name: N-(2-Hydroxyethyl)phthalimide
Synonyms: N-(2-HYDROXYETHYL)PHTHALIMIDE;AKOS BBS-00004429;TIMTEC-BB SBB003638;2-PHTHALIMIDOETHANOL;N-Hydroxyethylphthal;Amlodipine Impurity Q;Alogliptin impurity Q;N-hydroethyl phthalimide;N-HYDROXYETHYLPHTHALIMIDE;2-Hydroxyethylphthalimide
CBNumber: CB4241489
Molecular Formula: C10H9NO3
Formula Weight: 191.18
MOL File: 3891-07-4.mol

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N-(2-Hydroxyethyl)phthalimide Property

Melting point:: 126-128 °C(lit.)
Boiling point:: 326.92°C (rough estimate)
Density: 1.2722 (rough estimate)
refractive index: 1.5310 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 14.40±0.10(Predicted)
color: White
BRN: 147214
InChI: InChI=1S/C10H9NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,12H,5-6H2
InChIKey: MWFLUYFYHANMCM-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(=O)N1CCO
CAS DataBase Reference: 3891-07-4(CAS DataBase Reference)
NIST Chemistry Reference: N-2-hydroxyethyl phthalimide(3891-07-4)
EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-26-36/37/39-24/25
WGK Germany: 3
TSCA: TSCA listed
HS Code: 29251900
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 138339
Product name: N-(2-Hydroxyethyl)phthalimide
Purity: 99%
Packaging: 100g
Price: $103.55
Updated: 2025/07/31

TCI Chemical

Product number: H0245
Product name: N-(2-Hydroxyethyl)phthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: H0245
Product name: N-(2-Hydroxyethyl)phthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 500g
Price: $317
Updated: 2025/07/31

TRC

Product number: H949490
Product name: N-(2-Hydroxyethyl)phthalimide
Packaging: 100g
Price: $180
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK282856
Product name: N-(2-Hydroxyethyl)phthalimide
Purity: 99%
Packaging: 25g
Price: $24
Updated: 2021/12/16

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N-(2-Hydroxyethyl)phthalimide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601

General Description

N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.

Synthesis

A synthetic method of N-(2-Hydroxyethyl)phthalimide. It was prepared by allowing 147.2g (1.0 mole) of phthalimide to react in an autoclave with 53.0g (1.20 moles) of ethylene oxide in the presence of 1.47g (1%) of active chromium III tri-2-ethylhexanoate (COT) and 400 ml of methylisobutyl ketone (MiBK) at 160° to 165°C for two hours. On cooling, the N-(2-Hydroxyethyl)phthalimide crystallized and was collected by filtration. A 94.7% yield of the hydroxyethyl imide was obtained.

N-(2-Hydroxyethyl)phthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-Hydroxyethyl)phthalimide Suppliers

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View Lastest Price from N-(2-Hydroxyethyl)phthalimide manufacturers

YiZheng HaiFan Chemical CO., LTD.

Product: N-(2-hydroxyethyl)phthalimide 3891-07-4
Price: US $0.00/kgs/paper bag
Min. Order: 25kgs/paper bag
Purity: 99%
Supply Ability: 20 tons
Release date: 2026-01-05

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-Hydroxyethylphthalimide 3891-07-4
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Hydroxyethylphthalimide 3891-07-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

3891-07-4, N-(2-Hydroxyethyl)phthalimideRelated Search:

3-Nitrophthalimide Bismaleimide N-Methylphthalimide Succinimide 4-Nitrophthalimide 2-(METHYLSULFONYL)ETHANOL Methyl 2-hydroxyethyl cellulose Hydroxyethyl starch Hydroxyethyl Cellulose O-Phthalimide Potassium phthalimide 4-Aminophthalimide N-Hydroxyphthalimide Aztreonam Amide N-CHLOROSACCHARIN N-(Hydroxymethyl)phthalimide Desmethyl amolodipine Amlodipine Impurity 26

AKOS BBS-00004429

2-PHTHALIMIDOETHANOL

2-(2-hydroxyethyl)-1h-isoindole-1,3(2h)-dione

N-HYDROXYETHYLPHTHALIMIDE

N-(2-HYDROXYETHYL)PHTHALIMIDE

N-(BETA-HYDROXYETHYL)PHTHALIMIDE

TIMTEC-BB SBB003638

1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)-

2-(2-hydroxyethyl)-1h-isoindole-3(2h)-dione

2-Hydroxyethylphthalimide

Phthalimide, N-(2-hydroxyethyl)-

N- hydroxyethyl ortho - two - methimide

AMlodipine Related IMpurity 6 (N-(2-Hydroxyethyl)phthaliMide)

N-(2-Hydroxyethyl)phthaliMide, >=97.0%

<i>N-</i>(2-Hydroxyethyl)phthalimide

N-(2-Hydroxyethyl)phthalimide 99%

N-hydroethyl phthalimide

N-(2-Hydroxyethyl)phthalimide, 98+%

N-(2-Hydroxyethyl)phthalimide,99%

N-Hydroxyethylphthal

N-(2-Hydroxyethyl)phthaliMide, 99% 25GR

Amlodipine Impurity Q

N-(2-Hydroxyethyl)phthalimide&gt

Alogliptin impurity Q

N-(2-Hydroxylethyl) Phthalimide

N-(2-Hydroxyethyl)phthalimide (Imide)

2-(3,3-dimethylbutan-2-ylcarbamoyl)benzoic acid

N-(2-HYDROXYETHYL) PHTHALIMIDE For synthesis

N-Hydroxyethylphthalimide End use: Phthaloyl Amlodipine

3891-07-4

891-07-4

389-07-4

3891-7-4

727-38-4

Organic Building Blocks

Cyclic Imides

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

Building Blocks

Carbonyl Compounds

ALCOHOL

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Cyclic Imides

Organic Building Blocks

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

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