N-(Hydroxymethyl)phthalimide

Product Name: N-(Hydroxymethyl)phthalimide
CAS No.: 118-29-6
Chemical Name: N-(Hydroxymethyl)phthalimide
Synonyms: AURORA KA-454;N-(HydroxymethyL;AKOS BBS-00004724;PHTHALIMIDOMETHANOL;IFLAB-BB F0777-0575;N-(Hydroxymethyl)ph;oxymethylphthalimide;Phthalimidylmethanol;N-Methylolphthalimide;Oxymethyl phthalimide
CBNumber: CB1392676
Molecular Formula: C9H7NO3
Formula Weight: 177.16
MOL File: 118-29-6.mol

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N-(Hydroxymethyl)phthalimide Property

Melting point:: 147-149 °C (lit.)
Boiling point:: 309.06°C (rough estimate)
Density: 1.3312 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: Store below +30°C.
form: Fine Crystalline Powder
pka: 13.17±0.10(Predicted)
color: White
BRN: 140946
InChIKey: MNSGOOCAMMSKGI-UHFFFAOYSA-N
CAS DataBase Reference: 118-29-6(CAS DataBase Reference)
NIST Chemistry Reference: 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6)
EPA Substance Registry System: N-(Hydroxymethyl)phthalimide (118-29-6)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TI5270000
TSCA: Yes
HS Code: 29251995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H41803
Product name: N-(Hydroxymethyl)phthalimide
Purity: 97%
Packaging: 100g
Price: $219
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14422
Product name: N-(Hydroxymethyl)-phthalimide
Purity: for synthesis
Packaging: 100g
Price: $68.9
Updated: 2024/03/01

TCI Chemical

Product number: H0648
Product name: N-Hydroxymethylphthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: H0648
Product name: N-Hydroxymethylphthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 250g
Price: $150
Updated: 2024/03/01

Alfa Aesar

Product number: B21292
Product name: N-(Hydroxymethyl)phthalimide, 97%
Packaging: 25g
Price: $24.65
Updated: 2024/03/01

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N-(Hydroxymethyl)phthalimide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents.

Uses

For amidomethylation of aromatics in triflic acid.

Preparation

To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C.
NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range.

Definition

ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068

N-(Hydroxymethyl)phthalimide Preparation Products And Raw materials

Raw materials

Phthalimide Ammonium hydroxide Formaldehyde Phthalic anhydride

Preparation Products

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N-(Hydroxymethyl)phthalimide Suppliers

Americas 1 Austria 1 Belgium 1 Canada 1 China 302 Europe 4 France 2 Germany 10 India 25 Japan 3 Russia 1 Slovakia 1 South Korea 1 Switzerland 3 United Kingdom 12 United States 32 Global 400

Jiangsu lianrun chemical co. LTD

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View Lastest Price from N-(Hydroxymethyl)phthalimide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-(Hydroxymethyl)phthalimide 118-29-6
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10000kg
Release date: 2021-09-14

Hebei Chuanghai Biotechnology Co,.LTD

Product: N-(Hydroxymethyl)phthalimide 118-29-6
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg
Release date: 2024-08-21

Zibo Hangyu Biotechnology Development Co., Ltd

Product: N-(Hydroxymethyl)phthalimide 118-29-6
Price: US $90.00-900.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-31

118-29-6, N-(Hydroxymethyl)phthalimideRelated Search:

N-Hydroxyethylphthalimide N-Hydroxyphthalimide N-CHLOROSACCHARIN N-(Chloromethyl)phthalimide Isoindoline O-Phthalimide 3,4,5,6-Tetrahydro-N-(hydroxymethyl)phthalimide N-(Hydroxymethyl)phthalimide 2-[(3-CHLOROPHENOXY)METHYL]-1H-ISOINDOLE-1,3(2H)-DIONE AURORA KA-8051 4-NITRO-N-CARBOETHOXYPHTHALIMIDE N-Carbethoxyphthalimide

2-methylolisoindoline-1,3-quinone

N-(HydroxymethyL

PHTHALIMIDOMETHANOL

N-(HYDROXYMETHYL)PHTHALIMIDE

HYDROXYMETHYL PHTHALIMIDE

IFLAB-BB F0777-0575

AURORA KA-454

2-(hydroxymethyl)-1h-isoindole-3(2h)-dione

2-Hydroxymethyl-isoindole-1,3-dione

Methanol, phthalimido-

n-(hydroxymethyl)-phthalimid

N-Methylolphthalimide

Oxymethyl phthalimide

AKOS BBS-00004724

2-(HYDROXYMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE

oxymethylphthalimide

Phthalimide, N-(hydroxymethyl)-

Phthalimidomethyl alcohol

phthalimidomethylalcohol

4-(Hydroxymethyl)phthalimide, 97%

1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)-

N-Hydroxymethylphthalimide, 97 %

N-(Hydroxymethyl)phthalimide, 98+%

2-(Hydroxymethyl)-1,3-dihydro-2H-isoindole-1,3-dione

2-(Hydroxymethyl)isoindoline-1,3-dione

Phthalimidylmethanol

N-(Hydroxymethyl)phthalimide,Phthalimidomethanol

N-(Hydroxymethyl)ph

2-(hydroxymethyl)-1,3-isoindolinedione

2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, (Phthalimid-1-yl)methanol

N-(HydroxyMrthyl)phthaliMide

N-(HYDROXYMETHYL)-PHTHALIMIDE FOR SYNTHE

N- hydroxyMethyladjacent benzenetwoMethyl iMide

N - hydroxy Methyl phthalates forMyl iMine

<i>N-</i>Hydroxymethylphthalimide

2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, 2-(Hydroxymethyl)isoindolin-1,3-dione

N-Hydroxymethylphthalimide&gt

N-Hydroxyl-Methyl phthalimide

2-ACETYL-5-CHLORO-73-METHYLTHIANAPHTHENE

N-(-2-HYDROXYMETHYL) PHTHALIMIDE

118-29-6

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

ALCOHOL

Organic Building Blocks

Cyclic Imides

Carbonyl Compounds

Building Blocks

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

intermediates

fine chemicals

pharmacetical