ChemicalBook > CAS DataBase List > N-(Hydroxymethyl)phthalimide

N-(Hydroxymethyl)phthalimide

Product Name
N-(Hydroxymethyl)phthalimide
CAS No.
118-29-6
Chemical Name
N-(Hydroxymethyl)phthalimide
Synonyms
AURORA KA-454;N-(HydroxymethyL;AKOS BBS-00004724;PHTHALIMIDOMETHANOL;IFLAB-BB F0777-0575;N-(Hydroxymethyl)ph;oxymethylphthalimide;Phthalimidylmethanol;N-Methylolphthalimide;Oxymethyl phthalimide
CBNumber
CB1392676
Molecular Formula
C9H7NO3
Formula Weight
177.16
MOL File
118-29-6.mol
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N-(Hydroxymethyl)phthalimide Property

Melting point:
147-149 °C (lit.)
Boiling point:
309.06°C (rough estimate)
Density 
1.3312 (rough estimate)
refractive index 
1.5200 (estimate)
storage temp. 
Store below +30°C.
form 
Fine Crystalline Powder
pka
13.17±0.10(Predicted)
color 
White
BRN 
140946
InChIKey
MNSGOOCAMMSKGI-UHFFFAOYSA-N
CAS DataBase Reference
118-29-6(CAS DataBase Reference)
NIST Chemistry Reference
1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6)
EPA Substance Registry System
N-(Hydroxymethyl)phthalimide (118-29-6)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TI5270000
TSCA 
Yes
HS Code 
29251995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H41803
Product name
N-(Hydroxymethyl)phthalimide
Purity
97%
Packaging
100g
Price
$219
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14422
Product name
N-(Hydroxymethyl)-phthalimide
Purity
for synthesis
Packaging
100g
Price
$68.9
Updated
2024/03/01
TCI Chemical
Product number
H0648
Product name
N-Hydroxymethylphthalimide
Purity
>98.0%(HPLC)(N)
Packaging
25g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
H0648
Product name
N-Hydroxymethylphthalimide
Purity
>98.0%(HPLC)(N)
Packaging
250g
Price
$150
Updated
2024/03/01
Alfa Aesar
Product number
B21292
Product name
N-(Hydroxymethyl)phthalimide, 97%
Packaging
25g
Price
$24.65
Updated
2024/03/01
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N-(Hydroxymethyl)phthalimide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents.

Uses

For amidomethylation of aromatics in triflic acid.

Preparation

To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C.
NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range.

Definition

ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068

N-(Hydroxymethyl)phthalimide Preparation Products And Raw materials

Raw materials

Phthalimide Ammonium hydroxide Formaldehyde Phthalic anhydride

Preparation Products

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View Lastest Price from N-(Hydroxymethyl)phthalimide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
N-(Hydroxymethyl)phthalimide 118-29-6
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
99%min
Supply Ability
10000kg
Release date
2021-09-14
Hebei Chuanghai Biotechnology Co,.LTD
Product
N-(Hydroxymethyl)phthalimide 118-29-6
Price
US $9.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg
Release date
2024-08-21
Zibo Hangyu Biotechnology Development Co., Ltd
Product
N-(Hydroxymethyl)phthalimide 118-29-6
Price
US $90.00-900.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-31

118-29-6, N-(Hydroxymethyl)phthalimideRelated Search:

N-Hydroxyethylphthalimide N-Hydroxyphthalimide N-CHLOROSACCHARIN N-(Chloromethyl)phthalimide Isoindoline O-Phthalimide 3,4,5,6-Tetrahydro-N-(hydroxymethyl)phthalimide N-(Hydroxymethyl)phthalimide 2-[(3-CHLOROPHENOXY)METHYL]-1H-ISOINDOLE-1,3(2H)-DIONE AURORA KA-8051 4-NITRO-N-CARBOETHOXYPHTHALIMIDE N-Carbethoxyphthalimide

  • 2-methylolisoindoline-1,3-quinone
  • N-(HydroxymethyL
  • PHTHALIMIDOMETHANOL
  • N-(HYDROXYMETHYL)PHTHALIMIDE
  • HYDROXYMETHYL PHTHALIMIDE
  • IFLAB-BB F0777-0575
  • AURORA KA-454
  • 2-(hydroxymethyl)-1h-isoindole-3(2h)-dione
  • 2-Hydroxymethyl-isoindole-1,3-dione
  • Methanol, phthalimido-
  • n-(hydroxymethyl)-phthalimid
  • N-Methylolphthalimide
  • Oxymethyl phthalimide
  • AKOS BBS-00004724
  • 2-(HYDROXYMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  • oxymethylphthalimide
  • Phthalimide, N-(hydroxymethyl)-
  • Phthalimidomethyl alcohol
  • phthalimidomethylalcohol
  • 4-(Hydroxymethyl)phthalimide, 97%
  • 1H-Isoindole-1,3(2H)-dione, 2-(hydroxymethyl)-
  • N-Hydroxymethylphthalimide, 97 %
  • N-(Hydroxymethyl)phthalimide, 98+%
  • 2-(Hydroxymethyl)-1,3-dihydro-2H-isoindole-1,3-dione
  • 2-(Hydroxymethyl)isoindoline-1,3-dione
  • Phthalimidylmethanol
  • N-(Hydroxymethyl)phthalimide,Phthalimidomethanol
  • N-(Hydroxymethyl)ph
  • 2-(hydroxymethyl)-1,3-isoindolinedione
  • 2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, (Phthalimid-1-yl)methanol
  • N-(HydroxyMrthyl)phthaliMide
  • N-(HYDROXYMETHYL)-PHTHALIMIDE FOR SYNTHE
  • N- hydroxyMethyladjacent benzenetwoMethyl iMide
  • N - hydroxy Methyl phthalates forMyl iMine
  • <i>N-</i>Hydroxymethylphthalimide
  • 2-(Hydroxymethyl)-1H-isoindole-1,3(2H)-dione, 2-(Hydroxymethyl)isoindolin-1,3-dione
  • N-Hydroxymethylphthalimide&gt
  • N-Hydroxyl-Methyl phthalimide
  • 2-ACETYL-5-CHLORO-73-METHYLTHIANAPHTHENE
  • N-(-2-HYDROXYMETHYL) PHTHALIMIDE
  • 118-29-6
  • N-Substituted Maleimides, Succinimides & Phthalimides
  • N-Substituted Phthalimides
  • ALCOHOL
  • Organic Building Blocks
  • Cyclic Imides
  • Carbonyl Compounds
  • Building Blocks
  • N-Substituted Maleimides, Succinimides & Phthalimides
  • N-Substituted Phthalimides
  • intermediates
  • fine chemicals
  • pharmacetical