ChemicalBook > CAS DataBase List > Methyl 2,2-dithienylglycolate
Methyl 2,2-dithienylglycolate
- Product Name
- Methyl 2,2-dithienylglycolate
- CAS No.
- 26447-85-8
- Chemical Name
- Methyl 2,2-dithienylglycolate
- Synonyms
- Compound PDK0140;Aclidinium Impurity 5;2,2-dithienylglycolate;Tiotropium EP Impurity E;Aclidinium bromide impurity;China 2 2-dithienylglycolate;TiotropiuM BroMide IMpurity E;Methyl di(2-thienyl)glycolate;METHYL 2,2-DITHIENYL GLYCOLATE;Tiotropium Bromide BP Impurity E
- CBNumber
- CB0120838
- Molecular Formula
- C11H10O3S2
- Formula Weight
- 254.32
- MOL File
- 26447-85-8.mol
More
Less
Methyl 2,2-dithienylglycolate Property
- Melting point:
- 93-95°C
- Boiling point:
- 406.5±40.0 °C(Predicted)
- Density
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 10.43±0.29(Predicted)
- color
- White to Light Brown
- InChI
- InChI=1S/C11H10O3S2/c1-14-10(12)11(13,8-4-2-6-15-8)9-5-3-7-16-9/h2-7,13H,1H3
- InChIKey
- SYHWYWHVEQQDMO-UHFFFAOYSA-N
- SMILES
- C(C1SC=CC=1)(C1SC=CC=1)(O)C(=O)OC
- CAS DataBase Reference
- 26447-85-8(CAS DataBase Reference)
More
Less
Safety
- HS Code
- 2934999090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- M303765
- Product name
- MethylDi(2-thienylglycolate)
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
Usbiological
- Product number
- 282400
- Product name
- Methyl 2,2-dithienylglycolate
- Packaging
- 50g
- Price
- $531
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W020702
- Product name
- 2-Thiopheneaceticacid,α-hydroxy-α-2-thienyl-,methylester
- Purity
- 99.98%
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 073138
- Product name
- Methyl 2,2-dithienylglycolate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $23
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W020702
- Product name
- 2-Thiopheneaceticacid,α-hydroxy-α-2-thienyl-,methylester
- Purity
- 99.98%
- Packaging
- 10g
- Price
- $29
- Updated
- 2021/12/16
More
Less
Methyl 2,2-dithienylglycolate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Methyl Di(2-thienylglycolate) (Tiotropium EP Impurity E) is an intermediate in the production of Tiotropium Bromide, a long-acting bronchodilator.
Synthesis
553-90-2
26447-85-8
Under nitrogen protection, 2-bromothiophene (9.68 mL, 0.1 mol) was slowly added dropwise to a stirred mixture of magnesium scrapings (2.7 g, 0.11 mol) and ether (100 mL), keeping the reaction temperature at 0 °C. Subsequently, the reaction mixture was warmed up to 35 °C with continuous stirring. Next, a solution of dimethyl oxalate (5.9 g, 0.05 mol) in ether (150 mL) was slowly added dropwise over a period of 3 hours. After the dropwise addition was completed, the reaction mixture was heated to reflux (45 °C) and maintained for 45 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and 1.25 M sulfuric acid (150 mL) was added. After stirring for 1 h at room temperature, the organic layer was separated and washed sequentially with dilute aqueous sodium bicarbonate (100 mL) and water (100 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting solid residue was recrystallized with carbon tetrachloride (1 g / 3 mL) to afford methyl 2,2-dithienyl ethanoate (7.68 g, 30 mmol, 60% yield).
References
[1] Patent: US2004/242622, 2004, A1. Location in patent: Page 29
Methyl 2,2-dithienylglycolate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Methyl 2,2-dithienylglycolate Suppliers
- Tel
- 0531-82375892 15553111391
- 3276840968@qq.com
- Country
- China
- ProdList
- 301
- Advantage
- 58
- Tel
- 0512-63263366 18912765016
- Fax
- 0512-6326 3366
- tongtf110@sina.com
- Country
- China
- ProdList
- 993
- Advantage
- 62
- Tel
- 186-7296-9259 18771307593
- 3919539926@qq.com
- Country
- China
- ProdList
- 4258
- Advantage
- 58
- Tel
- 531-87922518 15628888630
- 1029084569@qq.com
- Country
- China
- ProdList
- 361
- Advantage
- 58
- Tel
- 86-27-82330560
- Fax
- 86-27-82330547
- 2536851935@qq.com
- Country
- China
- ProdList
- 347
- Advantage
- 69
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2802
- Advantage
- 65
- Tel
- 010-81769521,89753524,81760121 15901403431
- Fax
- +86-10-81769652
- sales01@mediking.cn
- Country
- China
- ProdList
- 99
- Advantage
- 68
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 571-88199336 18957129209
- Fax
- 0571-88190523
- 309645123@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7471
- Advantage
- 65
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5645
- Advantage
- 65
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5158
- Advantage
- 50
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 400-8706899
- Fax
- 400-8706899
- hysj_bj.com
- Country
- China
- ProdList
- 3583
- Advantage
- 55
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 021-60549325 18616193163
- Fax
- 021-33250306
- Country
- China
- ProdList
- 4526
- Advantage
- 56
- Tel
- 025-52164950
- Fax
- 025-86800069
- Googlexu_0114@sina.com
- Country
- China
- ProdList
- 644
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10263
- Advantage
- 55
- Tel
- 19916721580
- Fax
- QQ：3154870176
- mafarm@126.com
- Country
- China
- ProdList
- 4542
- Advantage
- 58
- Tel
- 531-87153728 13805401165
- Fax
- 0531-87922099
- xufeng192@126.com
- Country
- China
- ProdList
- 106
- Advantage
- 58
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 027-88395709
- Fax
- 027-88391805
- Country
- China
- ProdList
- 429
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 400-106-2016 17800804092
- admin@infsci.com
- Country
- China
- ProdList
- 553
- Advantage
- 55
- Tel
- 025-58362220 0086-15250997978
- Fax
- 025-58362220
- sale@njxizebio.com
- Country
- China
- ProdList
- 4855
- Advantage
- 55
- Tel
- 15618758386; 15618758386
- Fax
- QQ:3004479444
- sales3@myuchem.com
- Country
- China
- ProdList
- 1988
- Advantage
- 55
More
Less
View Lastest Price from Methyl 2,2-dithienylglycolate manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- Methyl 2,2-dithienylglycolate 26447-85-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
Anhui Dexinjia Biopharm Co., Ltd
- Product
- Methyl di(2-thienyl) glycolate 26447-85-8
- Price
- US $300.00-7500.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- 5MT per month
- Release date
- 2020-04-01
Zibo Hangyu Biotechnology Development Co., Ltd
- Product
- Methyl 2,2-dithienylglycolate 26447-85-8
- Price
- US $60.00-600.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-07
26447-85-8, Methyl 2,2-dithienylglycolateRelated Search:
Methyl cinnamate
trans-Methyl crotonate
Methylparaben
Acetonitrile
Methyl glycolate
POLY(METHYL ACRYLATE)
Paraquat dichloride
Methyl acrylate
METHYL JASMONATE
2,2-Difluoroethanol
METHYL OCTADEDANOATE
Methyl acetate
Glycolic acid
Basic Violet 1
FATTY ACID METHYL ESTER MIX C8-C22
Kresoxim-methyl
Methanol
Tiotropium bromide