4-Chloro-2-hydroxybenzaldehyde
- Product Name
- 4-Chloro-2-hydroxybenzaldehyde
- CAS No.
- 2420-26-0
- Chemical Name
- 4-Chloro-2-hydroxybenzaldehyde
- Synonyms
- 4-Chlorosalicylaldehy;4-chlorosalicylaldehyde;4-Chlorosalicylaldehyde >4-chloro-2-hydoxybenzaldehye;4-chloro-2-hydoxybenzaldehyde;2-hydroxy-4-chlorobenzaldehyde;4-CHLORO-2-HYDROXY-BENZALDEHYDE;Benzaldehyde, 4-chloro-2-hydroxy-;4-Chloro-2-hydroxybenzaldehyde 98%;4-Chloro-2-hydroxy-benzaldehyde ,97%
- CBNumber
- CB0132552
- Molecular Formula
- C7H5ClO2
- Formula Weight
- 156.57
- MOL File
- 2420-26-0.mol
4-Chloro-2-hydroxybenzaldehyde Property
- Melting point:
- 45.0 to 49.0 °C
- Boiling point:
- 229.1±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- pka
- 7.21±0.10(Predicted)
- color
- Off-White to Pale Brown
- InChI
- InChI=1S/C7H5ClO2/c8-6-2-1-5(4-9)7(10)3-6/h1-4,10H
- InChIKey
- QNZWAJZEJAOVPN-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(Cl)C=C1O
- CAS DataBase Reference
- 2420-26-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C2653
- Product name
- 4-Chlorosalicylaldehyde
- Purity
- >95.0%(GC)(T)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- C2653
- Product name
- 4-Chlorosalicylaldehyde
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $310
- Updated
- 2025/07/31
- Product number
- C364295
- Product name
- 4-Chloro-2-hydroxybenzaldehyde
- Packaging
- 2.5g
- Price
- $330
- Updated
- 2021/12/16
- Product number
- C364295
- Product name
- 4-Chloro-2-hydroxybenzaldehyde
- Packaging
- 10g
- Price
- $715
- Updated
- 2021/12/16
- Product number
- HCH0023359
- Product name
- 4-CHLORO-2-HYDROXYBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1027.95
- Updated
- 2021/12/16
4-Chloro-2-hydroxybenzaldehyde Chemical Properties,Usage,Production
Uses
4-Chloro-2-hydroxybenzaldehyde is an intermediate used to prepare benzodiazepine diones as Hdm2 antagonists. It is also used to synthesize hydroxy-dimethyl-oxo-cyclohexenyl-dimethyl-tetrahydro-xanthenone as oral neuropeptide Y5 receptor antagonist.
Synthesis
50-00-0
108-43-0
2420-26-0
To a 1L three-necked round-bottomed flask was added 3-chlorophenol (33.6 g, 0.3 mol), anhydrous MgCl2 (85.7 g, 0.9 mmol), triethylamine (75.9 g, 0.75 mol) and anhydrous acetone (340 mL). The resulting solution was stirred at 25 °C for 30 min, followed by the addition of paraformaldehyde (45 g, 1.5 mol). The reaction mixture was heated to reflux for 5 h under nitrogen protection. When TLC monitoring showed complete consumption of the feedstock, the acetone was evaporated under reduced pressure. The residue was acidified to pH 3 with 10% hydrochloric acid solution and extracted with ethyl acetate (3 x 150 mL). The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a brownish-red oil (18.1 g, 43.1% yield), which can be used directly in subsequent reactions without further purification (Byun et al., 2008; Uini and Lars, 1999).
References
[1] Applied Organometallic Chemistry, 2018, vol. 32, # 2,
[2] Drug Metabolism and Disposition, 2017, vol. 45, # 12, p. 1354 - 1363
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 6, p. 1530 - 1536
[4] Organic Letters, 2015, vol. 17, # 23, p. 5824 - 5827
[5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 30, p. 7268 - 7274
4-Chloro-2-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-2-hydroxybenzaldehyde Suppliers
- Tel
- --
- Fax
- --
- info@pschemicals.com
- Country
- The Netherlands
- ProdList
- 2724
- Advantage
- 58
View Lastest Price from 4-Chloro-2-hydroxybenzaldehyde manufacturers
- Product
- 4-Chloro-2-hydroxybenzaldehyde 2420-26-0
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- 4-Chloro-2-hydroxybenzaldehyde 2420-26-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-25
- Product
- 4-Chloro-2-hydroxybenzaldehyde 2420-26-0
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-10-08