4'-CHLORO-2'-HYDROXYACETOPHENONE
- Product Name
- 4'-CHLORO-2'-HYDROXYACETOPHENONE
- CAS No.
- 6921-66-0
- Chemical Name
- 4'-CHLORO-2'-HYDROXYACETOPHENONE
- Synonyms
- 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one;4'-Chloro-2'-hydroxycetophone;4-CHLORO-2-HYDROXYACETOPHENONE;4'-CHLORO-2'-HYDROXYACETOPHENONE;4-Chloro-2-hydroxyacetophenone,97%;4'-Chloro-2'-hydroxyacetophenone >1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE;Ethanone, 1-(4-chloro-2-hydroxyphenyl)-;1-(4-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-chlorophenol
- CBNumber
- CB3251203
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 6921-66-0.mol
4'-CHLORO-2'-HYDROXYACETOPHENONE Property
- Melting point:
- 27-30°C
- Boiling point:
- 120-122°C 10mm
- Density
- 1.298±0.06 g/cm3(Predicted)
- refractive index
- 1.5750 to 1.5790
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- pka
- 9.20±0.10(Predicted)
- color
- White or Colorless to Yellow
- CAS DataBase Reference
- 6921-66-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2968
- Product name
- 4'-Chloro-2'-hydroxyacetophenone
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- C2968
- Product name
- 4'-Chloro-2'-hydroxyacetophenone
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $168
- Updated
- 2025/07/31
- Product number
- C368878
- Product name
- 1-(4-Chloro-2-hydroxyphenyl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0040210
- Product name
- 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one
- Purity
- 98.93%
- Packaging
- 10g
- Price
- $73
- Updated
- 2021/12/16
- Product number
- FC10750
- Product name
- 4'-Chloro-2'-hydroxyacetophenone
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
4'-CHLORO-2'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production
Preparation
Preparation by Fries rearrangement of 3-chlorophenyl acetate with aluminium chloride,
without solvent at 130–135° (74–75%) ], between 135° and 200° and 175–200° (85–89%)
with solvent, at r.t., in nitrobenzene (88%), in tetrachloroethane (50%) or in chlorobenzene.
Synthesis
99-91-2
6921-66-0
61124-56-9
The general procedure for the synthesis of 4'-chloro-2'-hydroxyacetophenone and 1-(4-chloro-3-hydroxyphenyl)ethanone from p-chloroacetophenone was as follows: 5 mL of acetonitrile was added to the reaction system as a solvent under the protection of an Ar atmosphere, followed by the addition of 2.69 mg (1 × 10^-2 mmol) of 1-methyl-3-cyanoquinoline salt as a photosensitizer and 2.80 mg (6 × 10^ -3 mmol) cobalt oxime complex 2 as cobalt catalyst. Next, 0.2 mmol of 4'-chloroacetophenone (where R1 is COCH3, R4 is Cl, and both R2 and R3 are H) and 2 mmol of H2O were added. the reaction was carried out at room temperature using a high-pressure mercury lamp irradiation for 5 hr. Upon completion of the reaction, the production of H2 was detected by gas chromatography (TCD) and the conversion of benzene was analyzed by gas chromatography (FID). Subsequently, the products were separated by column chromatography and identified using 1H NMR and mass spectrometry (MS) to confirm that the main products were 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone. The conversion of 4'-chloroacetophenone was 56%, with yields of 14% and 42% for 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone, respectively, and 56% for H2.
References
[1] Patent: CN107324975, 2017, A. Location in patent: Paragraph 0128-0129
4'-CHLORO-2'-HYDROXYACETOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-CHLORO-2'-HYDROXYACETOPHENONE manufacturers
- Product
- 4-Chloro-2-hydroxyacetophenone 6921-66-0
- Price
- US $130.00-240.00/g
- Min. Order
- 1g
- Purity
- 99.2%
- Supply Ability
- 20tons
- Release date
- 2025-08-13