ChemicalBook > CAS DataBase List > 4'-CHLORO-2'-HYDROXYACETOPHENONE

4'-CHLORO-2'-HYDROXYACETOPHENONE

Product Name
4'-CHLORO-2'-HYDROXYACETOPHENONE
CAS No.
6921-66-0
Chemical Name
4'-CHLORO-2'-HYDROXYACETOPHENONE
Synonyms
1-(4-Chloro-2-hydroxyphenyl)ethan-1-one;4'-Chloro-2'-hydroxycetophone;4-CHLORO-2-HYDROXYACETOPHENONE;4'-CHLORO-2'-HYDROXYACETOPHENONE;4-Chloro-2-hydroxyacetophenone,97%;4'-Chloro-2'-hydroxyacetophenone >1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE;Ethanone, 1-(4-chloro-2-hydroxyphenyl)-;1-(4-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-chlorophenol
CBNumber
CB3251203
Molecular Formula
C8H7ClO2
Formula Weight
170.59
MOL File
6921-66-0.mol
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4'-CHLORO-2'-HYDROXYACETOPHENONE Property

Melting point:
27-30°C
Boiling point:
120-122°C 10mm
Density 
1.298±0.06 g/cm3(Predicted)
refractive index 
1.5750 to 1.5790
storage temp. 
Sealed in dry,Room Temperature
form 
powder to lump to clear liquid
pka
9.20±0.10(Predicted)
color 
White or Colorless to Yellow
CAS DataBase Reference
6921-66-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2968
Product name
4'-Chloro-2'-hydroxyacetophenone
Purity
>96.0%(GC)
Packaging
5g
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
C2968
Product name
4'-Chloro-2'-hydroxyacetophenone
Purity
>96.0%(GC)
Packaging
25g
Price
$168
Updated
2025/07/31
TRC
Product number
C368878
Product name
1-(4-Chloro-2-hydroxyphenyl)ethanone
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0040210
Product name
1-(4-Chloro-2-hydroxyphenyl)ethan-1-one
Purity
98.93%
Packaging
10g
Price
$73
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC10750
Product name
4'-Chloro-2'-hydroxyacetophenone
Packaging
10g
Price
$75
Updated
2021/12/16
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4'-CHLORO-2'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

Preparation by Fries rearrangement of 3-chlorophenyl acetate with aluminium chloride,
without solvent at 130–135° (74–75%) ], between 135° and 200° and 175–200° (85–89%)
with solvent, at r.t., in nitrobenzene (88%), in tetrachloroethane (50%) or in chlorobenzene.

Synthesis

99-91-2

6921-66-0

61124-56-9

The general procedure for the synthesis of 4'-chloro-2'-hydroxyacetophenone and 1-(4-chloro-3-hydroxyphenyl)ethanone from p-chloroacetophenone was as follows: 5 mL of acetonitrile was added to the reaction system as a solvent under the protection of an Ar atmosphere, followed by the addition of 2.69 mg (1 × 10^-2 mmol) of 1-methyl-3-cyanoquinoline salt as a photosensitizer and 2.80 mg (6 × 10^ -3 mmol) cobalt oxime complex 2 as cobalt catalyst. Next, 0.2 mmol of 4'-chloroacetophenone (where R1 is COCH3, R4 is Cl, and both R2 and R3 are H) and 2 mmol of H2O were added. the reaction was carried out at room temperature using a high-pressure mercury lamp irradiation for 5 hr. Upon completion of the reaction, the production of H2 was detected by gas chromatography (TCD) and the conversion of benzene was analyzed by gas chromatography (FID). Subsequently, the products were separated by column chromatography and identified using 1H NMR and mass spectrometry (MS) to confirm that the main products were 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone. The conversion of 4'-chloroacetophenone was 56%, with yields of 14% and 42% for 4'-chloro-2'-hydroxyacetophenone and 4'-chloro-3'-hydroxyacetophenone, respectively, and 56% for H2.

References

[1] Patent: CN107324975, 2017, A. Location in patent: Paragraph 0128-0129

4'-CHLORO-2'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-CHLORO-2'-HYDROXYACETOPHENONE Suppliers

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View Lastest Price from 4'-CHLORO-2'-HYDROXYACETOPHENONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Chloro-2-hydroxyacetophenone 6921-66-0
Price
US $130.00-240.00/g
Min. Order
1g
Purity
99.2%
Supply Ability
20tons
Release date
2025-08-13

6921-66-0, 4'-CHLORO-2'-HYDROXYACETOPHENONERelated Search:

4'-CHLORO-2'-HYDROXYACETOPHENONE 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE 6-CHLORO-BENZOFURAN-3-ONE α-Chloro-p-hydroxyacetophenone,α-Chloro-4'-hydroxyacetophenone 2-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 2'-CHLORO-4'-HYDROXYACETOPHENONE 3'-Chloro-2'-hydroxyacetophenone 3',5'-DICHLORO-2'-HYDROXYACETOPHENONE 2'-CHLORO-4'-HYDROXYACETOPHENONE 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 5'-CHLORO-2'-HYDROXYACETOPHENONE,5-CHLORO-2-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone 1-CARBOXYL-5,7-DIBROMO-6-HYDROXY-2,3,4-TRICHLOROXANTHONE 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE 7-CHLORO-3-FORMYLCHROMONE 7-CHLORO-2-PHENYL-4H-CHROMEN-4-ONE 7-CHLOROCHROMONE-3-SULFONYLCHLORIDE 7-chloro-4-oxo-4H-chromene-2-carboxylic acid

  • 1-(4-CHLORO-2-HYDROXYPHENYL)ETHANONE
  • 4'-CHLORO-2'-HYDROXYACETOPHENONE
  • 4-CHLORO-2-HYDROXYACETOPHENONE
  • 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one
  • 1-(4-Chloro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-chlorophenol
  • 4-Chloro-2-hydroxyacetophenone,97%
  • 4'-Chloro-2'-hydroxyacetophenone &gt
  • Ethanone, 1-(4-chloro-2-hydroxyphenyl)-
  • 4'-Chloro-2'-hydroxycetophone
  • 6921-66-0
  • 6932-66-0
  • Adehydes, Acetals & Ketones
  • Chlorine Compounds
  • Aromatic Acetophenones & Derivatives (substituted)