1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Product Name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- CAS No.
- 23007-85-4
- Chemical Name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Synonyms
- MPTP;MPTP HCl;MPTP HYDROCHLORIDE;0MPTP hydrochloride;Methyl Hydrochloride;23007-85-4/28289-54-5;NSC 139654 Hydrochloride;Pethidine EP Impurity B HCl;1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&;1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
- CBNumber
- CB0133791
- Molecular Formula
- C12H16ClN
- Formula Weight
- 209.72
- MOL File
- 23007-85-4.mol
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Property
- Melting point:
- 249.0 to 254.0 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- White solid
- color
- white to off-white
- BRN
- 3707312
- Stability:
- Light Sensitive
- InChI
- InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
- InChIKey
- KOWJANGMTAZWDT-UHFFFAOYSA-N
- SMILES
- C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
- CAS DataBase Reference
- 23007-85-4
Safety
- Hazard Codes
- T
- Risk Statements
- 25-39/23/24/25-36/37/38
- Safety Statements
- 45-39-26
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- UT8358950
- HS Code
- 2933.39.9200
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H370Causes damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M0896
- Product name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Purity
- powder
- Packaging
- 10mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- M0896
- Product name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
- Purity
- powder
- Packaging
- 100mg
- Price
- $394
- Updated
- 2024/03/01
- Product number
- 5.06382
- Product name
- MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem
- Packaging
- 10mg
- Price
- $182
- Updated
- 2024/03/01
- Product number
- M2690
- Product name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- M2690
- Product name
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $241
- Updated
- 2024/03/01
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.
Uses
MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]
Biochem/physiol Actions
Dopaminergic neurotoxin.
Purification Methods
Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]
References
[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Suppliers
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- Product
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-28
- Product
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31