ChemicalBook > CAS DataBase List > 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Product Name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
CAS No.
23007-85-4
Chemical Name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Synonyms
MPTP;MPTP HCl;MPTP HYDROCHLORIDE;0MPTP hydrochloride;Methyl Hydrochloride;23007-85-4/28289-54-5;NSC 139654 Hydrochloride;Pethidine EP Impurity B HCl;1-METHYL-4-PHENYL-1 2 3 6-TETRAHYDROPYR&;1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
CBNumber
CB0133791
Molecular Formula
C12H16ClN
Formula Weight
209.72
MOL File
23007-85-4.mol
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Property

Melting point:
249.0 to 254.0 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
White solid
color 
white to off-white
BRN 
3707312
Stability:
Light Sensitive
InChI
InChI=1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChIKey
KOWJANGMTAZWDT-UHFFFAOYSA-N
SMILES
C1(=CCN(C)CC1)C1C=CC=CC=1.Cl
CAS DataBase Reference
23007-85-4
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Safety

Hazard Codes 
T
Risk Statements 
25-39/23/24/25-36/37/38
Safety Statements 
45-39-26
RIDADR 
2811
WGK Germany 
3
RTECS 
UT8358950
HS Code 
2933.39.9200
HazardClass 
6.1(b)
PackingGroup 
III
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M0896
Product name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Purity
powder
Packaging
10mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
M0896
Product name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
Purity
powder
Packaging
100mg
Price
$394
Updated
2024/03/01
Sigma-Aldrich
Product number
5.06382
Product name
MPTP Hydrochloride - CAS 23007-85-4 - Calbiochem
Packaging
10mg
Price
$182
Updated
2024/03/01
TCI Chemical
Product number
M2690
Product name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$82
Updated
2024/03/01
TCI Chemical
Product number
M2690
Product name
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$241
Updated
2024/03/01
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride is a dopaminergic neurotoxin that reportedly causes a severe and irreversible Parkinsonian condition in humans and monkeys.

Uses

MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent. MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress. The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.[Cayman Chemical]

Biochem/physiol Actions

Dopaminergic neurotoxin.

Purification Methods

Purify MPTP by recrystallisation from pKEst ~ Me2CO/isoPrOH. The free base has m 40-42o(from heptane), b 99-100o/1.3mm, 128-132o/12mm, (137-142o/0.8mm), n 25 1.5347. The hydrochloride has m 251-252o(from Me2CO/isoPrOH) [Schmidle & Mansfield J Am Chem Soc 78 425 1956, Defeudis Drug Dev Res 15 1 1988, Beilstein 20 III/IV 3240, 20/7 V 121.]

References

[1] Lun-Yi Zang, Hara P Misra. “Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride.” Molecular and Cellular Biochemistry 254 1–2 (2003): 131–6.
[2] Gregory L. Willis, Alan D. Robertson. “Recovery from experimental Parkinson’s disease in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride treated marmoset with the melatonin analogue ML-23.” Pharmacology Biochemistry and Behavior 80 1 (2005): Pages 9-26.
[3] Atsushi Fujita. “Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model.” Journal of Neuroinflammation (2018): 227.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Suppliers

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View Lastest Price from 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-28
Career Henan Chemical Co
Product
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride 23007-85-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

23007-85-4, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochlorideRelated Search:

4-Pyridineacetic acid hydrochloride Topotecan hydrochloride 3-Pyridylacetic acid hydrochloride 2,6-Lutidine Thiophanate-methyl Pyridine hydrochloride 2,4,6-Collidine 2-Pyridylacetic acid hydrochloride PHENYL VALERATE Bensulfuron methyl 4-Methylpyridine Kresoxim-methyl 4-Phenylpyridine Chlorodimethylphenylsilane Azamethiphos Methylparaben Methyl Methyl bromide

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  • NSC 139654 Hydrochloride
  • Methyl Hydrochloride
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Hydrochloride &gt
  • MPTP HCl
  • 23007-85-4/28289-54-5
  • 1,2,3,6-tetrahydro-1-methyl-4-phenyl-Pyridine hydrochloride (1:1)
  • Pethidine EP Impurity B HCl
  • 0MPTP hydrochloride
  • 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine
  • 23007-85-4
  • C12H15NHCl
  • Heterocyclic Compounds
  • Neurochemicals