ChemicalBook > CAS DataBase List > 3-ACETYL-BETA-BOSWELLIC ACID

3-ACETYL-BETA-BOSWELLIC ACID

Product Name
3-ACETYL-BETA-BOSWELLIC ACID
CAS No.
5968-70-7
Chemical Name
3-ACETYL-BETA-BOSWELLIC ACID
Synonyms
B-ACETYLBOSWELLIC ACID;Acetyl-β-boswellic acid;β-acetyl-Boswellic Acid;Acetyl-β-boswellic acid;3-Acetyl-(-boswellicacid;BOSWELLIC ACID, 3-ACETYL;BETA-ACETYLBOSWELLIC ACID;O-Acetyl-β-boswellic acid;3-Acetyl-β-boswellic acid;3-O-Acetyl-β-boswellic acid
CBNumber
CB0133948
Molecular Formula
C32H50O4
Formula Weight
498.74
MOL File
5968-70-7.mol
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3-ACETYL-BETA-BOSWELLIC ACID Property

Melting point:
157-161℃
Boiling point:
567℃
Density 
1.09
Flash point:
171℃
storage temp. 
-20°C Freezer
solubility 
Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Very Sligh
pka
4.32±0.70(Predicted)
color 
White to Off-White
LogP
10.270 (est)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89152
Product name
3-O-Acetyl-β-boswellic acid
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$655
Updated
2023/01/07
Cayman Chemical
Product number
11674
Product name
β-acetyl-Boswellic Acid
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
11674
Product name
β-acetyl-Boswellic Acid
Purity
≥95%
Packaging
5mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
11674
Product name
β-acetyl-Boswellic Acid
Purity
≥95%
Packaging
10mg
Price
$266
Updated
2024/03/01
TRC
Product number
A177770
Product name
3-O-Acetyl-β-boswellic acid
Packaging
10mg
Price
$235
Updated
2021/12/16
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3-ACETYL-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

Uses

Boswellic acids are pentacyclic triterpenes first isolated from the resin of Boswellia plants. They have anti-inflammatory and anti-arthritic actions in mice. β-acetyl-Boswellic acid is a non-reducing inhibitor of 5-lipoxygenase (5-LO) that shows selectivity for 5-LO over 12-LO or COX. When studied as a 1:1 mixture with α-acetyl-boswellic acid, it inhibits topoisomerase II activity and arrests cell cycling or induces apoptosis in cancer cells.[Cayman Chemical]

Biological Activity

β-acetyl-boswellic acid is a specific, nonreducing-type inhibitor of the 5-lo product formation with selectivity over 12-lo and cox [1][2].5-lipoxygenase (5-lo) is a member of the lipoxygenase family of enzymes and transforms efa substrates into leukotrienes.in rat peritoneal neutrophils, boswellic acids concentration dependently decreased the formation of leukotriene b4 from endogenous arachidonic acid. in isolated human platelets, boswellic acids in concentrations up to 400 μm did not impair the cyclooxygenase and 12-lipoxygenase [1]. in calcium/calcium ionophore-stimulated peritoneal neutrophils of rats, boswellic acids significantly decreased production of ltb4 and total 5-lipoxygenase products with ec50 value of about 30 μg/ml [2]. in six human myeloid leukemia cell lines, boswellic acid acetate, a 1:1 mixture of α-boswellic acid acetate and β-boswellic acid acetate induces apoptosis through caspase-mediated pathways [4].boswellic acids are pentacyclic triterpenes with putative anti-inflammatory effects. in a mouse model of osteoarthritis (oa), boswellic acid significantly attenuated articular cartilage erosion and significantly reduced knee synovitis and osteophyte formation. in synovium of mice, boswellic acid directly inhibit il-1β and tlr4 induced inflammatory cytokines production [3].

References

[1]. safayhi h, mack t, sabieraj j, et al. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. j pharmacol exp ther. 1992 jun;261(3):1143-6.
[2]. ammon hp, safayhi h, mack t, et al. mechanism of antiinflammatory actions of curcumine and boswellic acids. j ethnopharmacol. 1993 mar;38(2-3):113-9.
[3]. wang q, pan x, wong hh, et al. oral and topical boswellic acid attenuates mouse osteoarthritis. osteoarthritis cartilage. 2014 jan;22(1):128-32.
[4]. xia l, chen d, han r, et al. boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. mol cancer ther. 2005 mar;4(3):381-8.

3-ACETYL-BETA-BOSWELLIC ACID Preparation Products And Raw materials

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View Lastest Price from 3-ACETYL-BETA-BOSWELLIC ACID manufacturers

Career Henan Chemical Co
Product
3-ACETYL-BETA-BOSWELLIC ACID 5968-70-7
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-08-10

5968-70-7, 3-ACETYL-BETA-BOSWELLIC ACIDRelated Search:


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