EPROSARTAN

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Product Name: EPROSARTAN
CAS No.: 133040-01-4
Chemical Name: EPROSARTAN
Synonyms: Teveten;CS-1951;Navixen;EPROSARTAN;SKB 108566;SKF-108566J;SKF-108566);Eprosartan-d4;prop-1-en-1-yl);-1H-imidazol-1-yl)
CBNumber: CB0135346
Molecular Formula: C23H24N2O4S
Formula Weight: 424.51
MOL File: 133040-01-4.mol

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EPROSARTAN Property

Melting point:: 250-253°C
storage temp.: Sealed in dry,2-8°C
solubility: Dichloromethane (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow to Light Yellow
CAS DataBase Reference: 133040-01-4

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Safety

Hazardous Substances Data: 133040-01-4(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: E590100
Product name: Eprosartan
Packaging: 10mg
Price: $70
Updated: 2021/12/16

Matrix Scientific

Product number: 094012
Product name: Eprosartan
Purity: 95+%
Packaging: 1g
Price: $227
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000548
Product name: EPROSARTAN
Purity: 95.00%
Packaging: 1G
Price: $284.55
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006807
Product name: EPROSARTAN-D4
Purity: 95.00%
Packaging: 5MG
Price: $501.55
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D33956
Product name: Eprosartan-d6
Packaging: 1mg
Price: $600
Updated: 2021/12/16

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EPROSARTAN Chemical Properties,Usage,Production

Description

Teveten was launched in Germany for the treatment of hypertension. There are several ways in which it has been prepared, the shortest of which is four steps; beginning with displacement of 2-butyl-4-chloroimidazole-5-carboxaldehyde with methyl 4-(bromomethyl)benzoate. Teveten is an angiotensin Ⅱ antagonist selective for the AT, subtype receptor. It is a potent, highly selective, competitve antagonist with no agonist activity. Duration of action is similar to Enalapril (greater than 12 hr) but Teveten had a faster onset. While it is orally active, it rapidly dissociates from the receptor. This is contrary to its prolonged duration of action, which presumably results from slow removal from compartments within tissue, cells or matrix around the AT, receptor. It is not bound by BSA.

Chemical Properties

Light-Yellow Solid

Originator

SmithKline Beecham (UK)

Uses

Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Antihypertensive

Uses

Eprosartan is a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Eprosartan is an antihypertensive.

Uses

Eprosartan (E590100) impurity.

Definition

ChEBI: A member of the class of imidazoles and thiophenes that is an angiotensin II receptor antagonist used for the treatment of high blood pressure.

brand name

Teveten

Clinical Use

Angiotensin-II antagonist
Hypertension

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemia hypotension and renal impairment with ACE inhibitors and aliskiren.
Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity.
Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics.
Epoetin: increased risk of hyperkalaemia; antagonism of hypotensive effect.
Lithium: reduced excretion, possibility of enhanced lithium toxicity.
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.

Metabolism

Following oral and intravenous dosing with [14C] eprosartan in human subjects, eprosartan was the only drug-related compound found in the plasma and faeces. In the urine, approximately 20% of the radioactivity excreted was an acyl glucuronide of eprosartan with the remaining 80% being unchanged eprosartan
Eprosartan is eliminated by both biliary and renal excretion. Following intravenous [14C] eprosartan, about 61% of radioactivity is recovered in the faeces and about 37% in the urine. Following an oral dose of [14C] eprosartan, about 90% of radioactivity is recovered in the faeces and about 7% in the urine.

EPROSARTAN Preparation Products And Raw materials

Raw materials

Clotrimazole Methyl 4-(bromomethyl)benzoate 2-Carbethoxy-3-(2-thienyl)propanoic acid Methyl acrylate

Preparation Products

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EPROSARTAN Suppliers

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View Lastest Price from EPROSARTAN manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Eprosartan 133040-01-4
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

133040-01-4, EPROSARTANRelated Search:

SB 206328 CINITAPRIDE HYDROGEN TARTRATE 4-(2-BUTYL-5-FORMYLIMIDAZOL-1-YLMETHYL)BENZOIC ACID Tacrolimus Losartan potassium Pregabalin Irbesartan Valsartan Eprosartan mesylate Olmesartan Medoxomil Tasosartan 4-Bromomethylbenzoic acid SB 201972 3-(2-THIENYL)PROPIONIC ACID Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate Epalrestat iMpurity 4-(Hydroxymethyl)benzoic acid α-Methylcinnamaldehyde

4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzoic acid

CS-1951

EPROSARTAN

Eprosartan Mysylate

(E)-3-[2-Butyl-1-[(4-carboxyphenyl)-methyl]imidazol-5-l]-2-(2-thienylmethyl)-2-propenoic Acid

((E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic Acid

SKF-108566)

SKF-108566J

Teveten

(E)- α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-y1]methylene]2-thiophenepropanoic acid

(E)-3-[2-Butyl-1-(4-carboxybenzyl)-1H-imidazol-5-yl]-2-(2-thienylmethyl)acrylic acid

2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-

Des[2-(2-thienylMethyl)] Eprosartan-2-carboxylic Acid

(E)-2-Butyl-1-(p-carboxybenzyl)-α-2-thenyliMidazole-5-acrylic Acid

(αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)Methyl]-1H-iMidazol-5-yl]Methylene]-2-thiophenepropanoic Acid

Navixen

SKB 108566

2-[[2-Butyl-1-[[4-(carboxyphenyl)]Methyl]-1H-iMidazol-5-yl]Methylene]propanedioic Acid

4-[[2-Butyl-5-(2,2-dicarboxyvinyl)-1H-iMidazol-1yl)Methylbenzoic Acid

Eprosartan-d4

(E)-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1H-iMidazol-1-yl)Methyl)benzoic acid

-1H-imidazol-1-yl)

-4-((2-Butyl-5-(2-carboxy-3-(thiophen-2-yl)

prop-1-en-1-yl)

EPROSARTAN USP/EP/BP

Eprosartan D6 HClQ: What is Eprosartan D6 HCl Q: What is the CAS Number of Eprosartan D6 HCl Q: What is the storage condition of Eprosartan D6 HCl Q: What are the applications of Eprosartan D6 HCl

EprosartanQ: What is Eprosartan Q: What is the CAS Number of Eprosartan Q: What is the storage condition of Eprosartan Q: What are the applications of Eprosartan

TIANFU-CHEM EPROSARTAN

Eprosartan (SKF-108566J)

Eprosartan (E)-3-[2-Butyl-1-[(4-carboxyphenyl)methyl]-imidazol-5-yl]-2-(2- thienyl methyl)-2-propenoic acid

Eprosartan in methanol

133040-01-4

C23H24N2O4S

Aromatics

Heterocycles

Impurities

Intermediates

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds