Tasosartan
- Product Name
- Tasosartan
- CAS No.
- 145733-36-4
- Chemical Name
- Tasosartan
- Synonyms
- Verdia;CS-160;DB01349;ANA-756;AC1Q6LAA;AC1L1U5X;Tasosarta;TASOSARTAN;WAY-ANA-756;S1539_Selleck
- CBNumber
- CB2761688
- Molecular Formula
- C23H21N7O
- Formula Weight
- 411.46
- MOL File
- 145733-36-4.mol
Tasosartan Property
- Melting point:
- 197-199°
- Boiling point:
- 759.4±70.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 4.16±0.10(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 29495
- Product name
- Tasosartan
- Packaging
- 25mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 29495
- Product name
- Tasosartan
- Packaging
- 250mg
- Price
- $684
- Updated
- 2024/03/01
- Product number
- 29495
- Product name
- Tasosartan
- Packaging
- 50mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 29495
- Product name
- Tasosartan
- Packaging
- 100mg
- Price
- $292
- Updated
- 2024/03/01
- Product number
- 466818
- Product name
- Tasosartan
- Packaging
- 10mg
- Price
- $460
- Updated
- 2021/12/16
Tasosartan Chemical Properties,Usage,Production
Uses
Antihypertensive.
Uses
Tasosartan is an angiotensin II receptor antagonist.
Definition
ChEBI: Tasosartan is a member of biphenyls.
Synthesis
149049-80-9
145733-36-4
Step 6) A mixture of 2,4-dimethyl-5,6,8-trihydro-8-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one and 2,4-dimethyl-5,6,8-trihydro-8-[[2'-(1-tert-butyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4 -yl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one mixture (200 mg, 0.428 mmol) was dissolved in toluene (4 mL), methanesulfonic acid (280 mL, 4.28 mmol) was added, and heated to reflux for 18 hours. Upon completion of the reaction, the mixture was concentrated and adjusted to pH 8 by the addition of water (2 mL) and 1N KOH solution (4.5 mL).The mixture was extracted with ethyl acetate (EtOAc) to remove unreacted feedstock, followed by acidification of the aqueous phase to pH 5 with 1N HCl to give a gelatinous precipitate. The precipitate was dissolved in ethyl acetate and the solution was dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give a colorless oil. Grinding with a solvent mixture of acetone/ether gave 70 mg (40% yield) of the target product as a white solid with a melting point of 197°C-198°C.1H NMR (DMSO-d6) δ: 2.35 (s, 3H), 2.42 (s, 3H), 2.72 (t, J = 7.2 Hz, 2H), 2.87 (t, J = 7.2 Hz, 2H), 2.17 (s, 2H), 2.17 (s, 2H). 5.17 (s, 2H), 6.99 (d, J = 8.2 Hz, 2H), 7.18 (d, J = 8.2 Hz, 2H), 7.54 (m, 2H), 7.65 (m, 2H). ir (KBr, cm-1): 1710 (C=O).
in vivo
Administration of Tasosartan at doses of 1.0 and 3.0 mg/kg (iv) significantly (p<0.05) attenuates the pressor response to angiotensin-II in rats[2].
IC 50
AT1 Receptor
References
[1] Patent: US5256654, 1993, A
[2] Patent: US5149699, 1992, A
Tasosartan Preparation Products And Raw materials
Raw materials
Preparation Products
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