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isodiospyrin

Product Name
isodiospyrin
CAS No.
20175-84-2
Chemical Name
isodiospyrin
Synonyms
Isoquinone;isodiospyrin;Isodiospirin;[1,2'-BINAPHTHALENE]-5,5',8,8';1,2’-Binaphthalene-5,5’,8,8’-tet;[1,2’-Binaphtalene]-5,5’,8,8’-tet;(-)-1',4-Dihydroxy-2,3'-dimethyl-(1,2'-binaphthalene)-5,5',8,8'-tetrone;[1,2'-Binaphthalene]-5,5',8,8'-tetrone,1',4-dihydroxy-2,3'-dimethyl-, (1R)-;5-hydroxy-6-(4-hydroxy-2-methyl-5,8-dioxonaphthalen-1-yl)-7-methylnaphthalene-1,4-dione;IsodiospyrinQ: What is Isodiospyrin Q: What is the CAS Number of Isodiospyrin Q: What is the storage condition of Isodiospyrin
CBNumber
CB01361355
Molecular Formula
C22H14O6
Formula Weight
374.34
MOL File
20175-84-2.mol
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isodiospyrin Property

Melting point:
233 °C
Boiling point:
712.0±60.0 °C(Predicted)
Density 
1.495±0.06 g/cm3(Predicted)
pka
5.66±0.20(Predicted)
form 
Solid
color 
Orange to red
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

CSNpharm
Product number
CSN15179
Product name
Isodiospyrin
Packaging
1mg
Price
$425
Updated
2021/12/16
Arctom
Product number
CFN98019
Product name
Isodiospyrin
Packaging
5mg
Price
$593
Updated
2021/12/16
Crysdot
Product number
CD32002067
Product name
Isodiospyrin
Purity
95+%
Packaging
5mg
Price
$930
Updated
2021/12/16
CSNpharm
Product number
CSN15179
Product name
Isodiospyrin
Packaging
5mg
Price
$1062
Updated
2021/12/16
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isodiospyrin Chemical Properties,Usage,Production

Uses

Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].

Definition

ChEBI: Isodiospyrin is a member of biphenyls.

IC 50

Topoisomerase I

References

[1] Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. DOI:10.1016/j.bcp.2003.07.003
[2] B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. DOI:10.1002/(sici)1099-1573(200003)14:2<112::aid-ptr488>3.0.co;2-t
[3] Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. DOI:10.1002/cbdv.201000310

isodiospyrin Preparation Products And Raw materials

Raw materials

Preparation Products

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20175-84-2, isodiospyrinRelated Search:

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  • isodiospyrin
  • [1,2’-Binaphtalene]-5,5’,8,8’-tet
  • 1,2’-Binaphthalene-5,5’,8,8’-tet
  • [1,2'-BINAPHTHALENE]-5,5',8,8'
  • Isoquinone
  • (-)-1',4-Dihydroxy-2,3'-dimethyl-(1,2'-binaphthalene)-5,5',8,8'-tetrone
  • Isodiospirin
  • [1,2'-Binaphthalene]-5,5',8,8'-tetrone,1',4-dihydroxy-2,3'-dimethyl-, (1R)-
  • 5-hydroxy-6-(4-hydroxy-2-methyl-5,8-dioxonaphthalen-1-yl)-7-methylnaphthalene-1,4-dione
  • IsodiospyrinQ: What is Isodiospyrin Q: What is the CAS Number of Isodiospyrin Q: What is the storage condition of Isodiospyrin
  • 20175-84-2