4-Fluoro-2-methylphenol

Product Name: 4-Fluoro-2-methylphenol
CAS No.: 452-72-2
Chemical Name: 4-Fluoro-2-methylphenol
Synonyms: 4-FLUORO-O-CRESOL;4-Fluoro-2-methylphe;4-Fluoro-o-cresol>4-Fluoro-o-methylphenol;4-FLUORO-2-METHYLPHENOL;2-METHYL-4-FLUOROPHENOL;4-Fuoro-2-Methyl-phenol;5-Fluoro-2-hydroxytoluene;4-Fluoro-2-methylphenol99%;Phenol, 4-fluoro-2-methyl-
CBNumber: CB0136772
Molecular Formula: C7H7FO
Formula Weight: 126.13
MOL File: 452-72-2.mol

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4-Fluoro-2-methylphenol Property

Melting point:: 37-38 °C (lit.)
Boiling point:: 87 °C/14 mmHg (lit.)
Density: 1.1514 (estimate)
refractive index: 1.5155-1.5175
Flash point:: 185 °F
storage temp.: Inert atmosphere,Room Temperature
pka: 10.32±0.18(Predicted)
form: Low Melting Solid or Liquid
color: Off-white to brownish
Water Solubility: Insoluble in water.
BRN: 2041490
Major Application: environmental
InChI: InChI=1S/C7H7FO/c1-5-4-6(8)2-3-7(5)9/h2-4,9H,1H3
InChIKey: GKQDDKKGDIVDAG-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(F)C=C1C
CAS DataBase Reference: 452-72-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-21/22
Safety Statements: 26-36/37/39
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
HS Code: 29081990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 337129
Product name: 4-Fluoro-2-methylphenol
Purity: 99%
Packaging: 1g
Price: $39.33
Updated: 2025/07/31

TCI Chemical

Product number: F0387
Product name: 4-Fluoro-o-cresol
Purity: >98.0%(GC)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: F0387
Product name: 4-Fluoro-o-cresol
Purity: >98.0%(GC)
Packaging: 25g
Price: $235
Updated: 2021/12/16

TRC

Product number: F498570
Product name: 4-Fluoro-2-methylphenol
Packaging: 5g
Price: $120
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2701-3-01
Product name: 4-Fluoro-2-methylphenol
Purity: 98%
Packaging: 100g
Price: $169
Updated: 2021/12/16

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4-Fluoro-2-methylphenol Chemical Properties,Usage,Production

Chemical Properties

Off-white to brownish low melting solid or liquid

Uses

4-Fluoro-2-methylphenol is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.

General Description

Laccase mediated grafting of 4-fluoro-2-methylphenol with lignin model compound, dibenzodioxocin and lignocellulose material has been investigated.

Synthesis

Add 70g of water and 26g of concentrated sulfuric acid to the 250mL reaction flask (pay attention to exothermic, add concentrated sulfuric acid to water slowly, the same below), add 17.5g of 4-fluoro-2-methylaniline at room temperature while stirring, a white solid was produced, raise the temperature to 100~105 ??, completely dissolved, and reduce the temperature to 0 ??; slowly add 44.5g of nitrosyl sulfuric acid dropwise, control the temperature at -5~5 ??, hold the heat after dropwise The reaction solution was clarified for 2h to obtain the diazo solution. In another 250mL reaction bottle add 66g of water and 19g of concentrated sulfuric acid, warming to 110 ??, drop into the above prepared diazo liquid, control the drop acceleration, drop and add the side of water vapor distillation, so that the oil droplets continue to evaporate, the temperature is controlled at 110 ?? ~ 115 ??; drop and add the completion of the distillation continued for 2 hours, until no oil droplets evaporated; separation of the oil layer, add 11.1g content of 1% aqueous sodium hydroxide solution to wash, and the oil layer, the top temperature of 80 ??, and then the oil layer, the top temperature is 0 ??, the top temperature of 80 ??, the top temperature is 0 ??. Separate the oil layer, the top temperature of 80 ~ 90 ?? _x000D _ 10mmHg distillation, the product 4-fluoro-2-methylphenol 14.8g, GC: 99.5%, yield 83%.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5338 - 5341

4-Fluoro-2-methylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-2-methylphenol Suppliers

Americas 1 Belgium 3 China 185 Europe 3 France 2 Germany 6 India 8 Italy 1 Japan 2 Norway 1 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 22 United States 36 Global 274

Hunan Daolin Biotechnology Co. , Ltd.

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Nanjing XiLang Chemical Products Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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Energy Chemical

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Capot Chemical Co., Ltd

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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
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ProdList: 11997
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View Lastest Price from 4-Fluoro-2-methylphenol manufacturers

Hebei Fengjia New Material Co., Ltd

Product: 4-Fluoro-2-methylphenol 452-72-2
Price: US $4.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluoro-2-methylphenol 452-72-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Honest Joy Holdings Limited

Product: 4-Fluoro-2-methylphenol 452-72-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.7%
Supply Ability: 100 tons
Release date: 2022-02-21

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