1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
- Product Name
- 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
- CAS No.
- 394-32-1
- Chemical Name
- 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
- Synonyms
- 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5’-fluoro-2’-hydroxy-acetophenon;5'-FLUORO-2'-HYDROXYACETOPHENONE
- CBNumber
- CB6267638
- Molecular Formula
- C8H7FO2
- Formula Weight
- 154.14
- MOL File
- 394-32-1.mol
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Property
- Melting point:
- 56-58 °C(lit.)
- Boiling point:
- 65-66 °C8 mm Hg(lit.)
- Density
- 1.1850 (estimate)
- Flash point:
- 65-66°C/8mm
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 10.17±0.18(Predicted)
- color
- White to Gray to Brown
- Water Solubility
- Soluble 0.68 G/L
- BRN
- 2359087
- CAS DataBase Reference
- 394-32-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Fluoro-2-hydroxyacetophenone(394-32-1)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39-36/37/39
- WGK Germany
- 3
- RTECS
- AM8502300
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 247170
- Product name
- 5′-Fluoro-2′-hydroxyacetophenone
- Purity
- 98%
- Packaging
- 5g
- Price
- $31.3
- Updated
- 2024/03/01
- Product number
- 247170
- Product name
- 5′-Fluoro-2′-hydroxyacetophenone
- Packaging
- 1g
- Price
- $28.5
- Updated
- 2022/05/15
- Product number
- F0318
- Product name
- 5'-Fluoro-2'-hydroxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- F0318
- Product name
- 5'-Fluoro-2'-hydroxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $89
- Updated
- 2024/03/01
- Product number
- A15614
- Product name
- 5'-Fluoro-2'-hydroxyacetophenone, 98%
- Packaging
- 5g
- Price
- $61.7
- Updated
- 2021/12/16
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Usage,Production
Chemical Properties
light yellow to beige-brown crystals
Uses
5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:
- 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
- 3-hydroxy and 3-methoxyflavones
- 3-hydroxy and 3-methoxy 2-styrylchromones
Definition
ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.
Preparation
Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).
General Description
5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.
Synthesis
The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers
- Product
- 5'-Fluoro-2'-hydroxyacetophenone 394-32-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-20
- Product
- 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-09-06
- Product
- 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2023-04-24