1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

Product Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
CAS No.: 394-32-1
Chemical Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms: 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5’-fluoro-2’-hydroxy-acetophenon;5'-FLUORO-2'-HYDROXYACETOPHENONE
CBNumber: CB6267638
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 394-32-1.mol

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Property

Melting point:: 56-58 °C(lit.)
Boiling point:: 65-66 °C8 mm Hg(lit.)
Density: 1.1850 (estimate)
Flash point:: 65-66°C/8mm
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 10.17±0.18(Predicted)
color: White to Gray to Brown
Water Solubility: Soluble 0.68 G/L
BRN: 2359087
CAS DataBase Reference: 394-32-1(CAS DataBase Reference)
NIST Chemistry Reference: 5-Fluoro-2-hydroxyacetophenone(394-32-1)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-37/39-36/37/39
WGK Germany: 3
RTECS: AM8502300
HazardClass: IRRITANT
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 247170
Product name: 5′-Fluoro-2′-hydroxyacetophenone
Purity: 98%
Packaging: 5g
Price: $31.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 247170
Product name: 5′-Fluoro-2′-hydroxyacetophenone
Packaging: 1g
Price: $28.5
Updated: 2022/05/15

TCI Chemical

Product number: F0318
Product name: 5'-Fluoro-2'-hydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: F0318
Product name: 5'-Fluoro-2'-hydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: A15614
Product name: 5'-Fluoro-2'-hydroxyacetophenone, 98%
Packaging: 5g
Price: $61.7
Updated: 2021/12/16

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige-brown crystals

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
3-hydroxy and 3-methoxyflavones
3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers

Americas 1 Belgium 2 Canada 1 China 252 Europe 5 France 2 Germany 5 India 34 Italy 1 Japan 3 Slovakia 1 Switzerland 3 Ukraine 2 United Kingdom 20 United States 51 Global 383

Clearsynth Labs Limited

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View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers

Nanjing Fred Technology Co., Ltd

Product: 5'-Fluoro-2'-hydroxyacetophenone 394-32-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Hebei Mojin Biotechnology Co.,Ltd

Product: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-09-06

Zhengzhou Anbu Chem Co.,Ltd

Product: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-04-24

394-32-1, 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanoneRelated Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 6-Fluoro-4-chromanone 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-6'-HYDROXYACETOPHENONE 1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-Fluoro-2'-hydroxyacetophenone 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 2'-Hydroxyacetophenone 4-Fluorophenol 6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE (E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER

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5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one

2-Hydroxy-5-Fluoroacetophenone99%

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5'-Fluoro-2'-hydroxyacetophenone&gt

2-hydroxy-5-fluorophenone

5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone

TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluor-2-hydroxyphenyl)ethan-1-on

1-(5-fluro-2-hydroxyphenyl)ethanone

5'-Fluoro-2'-hydroxyacetophenone

394-32-1

Building Blocks

Carbonyl Compounds

C7 to C8

KETONE

Ketones

Organic Building Blocks

Aryl Fluorinated Building Blocks

Building Blocks

C7 to C8

C7-C8

Chemical Synthesis

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Acetophenone series

Adehydes, Acetals & Ketones

Fluorine Compounds

Phenols

C7 to C8

Carbonyl Compounds

Ketones

Aromatic Acetophenones & Derivatives (substituted)

ketone

(intermediate of nebivolol)

Benzenes

Alcohols and Derivatives

Carbonyl Compounds

1