demethylzeylasteral
- Product Name
- demethylzeylasteral
- CAS No.
- 107316-88-1
- Chemical Name
- demethylzeylasteral
- Synonyms
- demethylzeylasteral;Demethylzeylasteral-RM;Demethylzeylasteral(T-96);Demethylzeylasteral, 10 mM in DMSO;A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid;24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-;(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid;(2R,4AS,6aS,12bR,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,12b,14a-pentamethyl-8-oxo-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
- CBNumber
- CB01371631
- Molecular Formula
- C29H36O6
- Formula Weight
- 480.59
- MOL File
- 107316-88-1.mol
demethylzeylasteral Property
- Melting point:
- >221°C (dec.)
- Boiling point:
- 663.6±55.0 °C(Predicted)
- Density
- 1.31
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 4.78±0.70(Predicted)
- color
- Yellow
- Major Application
- food and beverages
- InChIKey
- ZDZSFWLPCFRASW-CPISFEQASA-N
- SMILES
- Oc1c(c2c(cc1O)[C@@]3(CC[C@]4([C@H]5[C@@](CC[C@@]4(C3=CC2=O)C)(CC[C@@](C5)(C)C(=O)O)C)C)C)C=O
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28595
- Product name
- Demethylzeylasteral
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 28595
- Product name
- Demethylzeylasteral
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
- Product number
- 28595
- Product name
- Demethylzeylasteral
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- D231408
- Product name
- Demethylzeylasteral
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 300174
- Product name
- Demethylzeylasteral
- Packaging
- 20mg
- Price
- $320
- Updated
- 2021/12/16
demethylzeylasteral Chemical Properties,Usage,Production
Chemical Properties
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.
Uses
Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.
Definition
ChEBI: A carbopolycyclic compound with formula C29H36O6, originally isolated from Tripterygium wilfordii.
Synthesis
Lei Gong Teng herbs crushed, weighed 500g, add 3L 70% ethanol ultrasonic extraction twice, extraction time for 20min, power 500W, combined extracts, concentrated to extract, add 200mlpH8 of sodium bicarbonate solution to dissolve, filtration, filtrate with . Hydrochloric acid adjusted to pH 6.5, add 300 ml of ethyl acetate extraction 2 times, combined with the extract, evaporated to get the crude demethyl zeylanol aldehyde; demethyl zeylanol aldehyde crude dissolved in methanol, microporous filtration membrane filtration, by the preparation of high-performance liquid chromatographic separation, chromatographic column: octadecyl bond and silica gel, mobile phase: acetonitrile - water (40:60), to monitor the guidance of the refractive detector monitoring The product was collected, and the collected liquid was concentrated and dried to obtain 1.42g, the content was 98.7%.
in vivo
Demethylzeylasteral (30 mg/kg, 6 times every 2 days, i.p.) inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis[1]. Demethylzeylasteral (4 mg/kg, 5 weeks, i.p.) inhibits the invasion of triple negative breast cancer by blocking classical and non classical TGF - β signaling pathways[2]. Demethylzeylasteral (30-120 mg/kg, 8 weeks, i.p.) improves inflammation in a unilateral ureteral obstruction rat model by inhibiting the activation of the NF - κ B pathway[4]. Demethylzeylasteral (10, 40 mg/kg, 30 days, i.g.) can alleviate atherosclerosis in AS rabbits[5]. Demethylzeylasteral (10, 20 mg/kg, 4 weeks, p.o.) improves CCl4 induced liver fibrosis in mice by inhibiting AGAP2 mediated FAK/AKT signaling[6].
| Animal Model: | Female nude mice modeled with glioma LN-229 cells[1]. |
| Dosage: | 30 mg/kg, 6 times every 2 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced tumor volume |
| Animal Model: | Female BALB/c mice modeled with 4T1 cells[2]. |
| Dosage: | 4 mg/kg, 5 weeks |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Reduced cancer lung metastasis |
| Animal Model: | Rat model of unilateral ureteral obstruction[4]. |
| Dosage: | 30-120 mg/kg, 8 weeks |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Inhibited the increases in serum creatinine, blood urea nitrogen and Up/Ucr ratio |
| Animal Model: | Atherosclerotic rabbit[5]. |
| Dosage: | 10, 40 mg/kg, 30 days |
| Administration: | Intragastrical (i.g.) |
| Result: | Reduced blood lipids triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C) |
| Animal Model: | CCl4-induced liver fibrosis model[6]. |
| Dosage: | 10, 20 mg/kg, 4 weeks |
| Administration: | Oral gavage (p.o.) |
| Result: | Inhibited the expression of TGF-β1 |
demethylzeylasteral Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from demethylzeylasteral manufacturers
- Product
- demethylzeylasteral 107316-88-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2025-06-27
- Product
- Demethylzeylasteral 107316-88-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-13
- Product
- demethylzeylasteral 107316-88-1
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10000kg
- Release date
- 2018-08-10