demethylzeylasteral

Product Name: demethylzeylasteral
CAS No.: 107316-88-1
Chemical Name: demethylzeylasteral
Synonyms: demethylzeylasteral;Demethylzeylasteral-RM;Demethylzeylasteral(T-96);Demethylzeylasteral, 10 mM in DMSO;A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid;24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-;(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid;(2R,4AS,6aS,12bR,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,12b,14a-pentamethyl-8-oxo-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
CBNumber: CB01371631
Molecular Formula: C29H36O6
Formula Weight: 480.59
MOL File: 107316-88-1.mol

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demethylzeylasteral Property

Melting point:: >221°C (dec.)
Boiling point:: 663.6±55.0 °C(Predicted)
Density: 1.31
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.78±0.70(Predicted)
color: Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28595
Product name: Demethylzeylasteral
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 28595
Product name: Demethylzeylasteral
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Cayman Chemical

Product number: 28595
Product name: Demethylzeylasteral
Packaging: 1mg
Price: $32
Updated: 2024/03/01

TRC

Product number: D231408
Product name: Demethylzeylasteral
Packaging: 1mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 300174
Product name: Demethylzeylasteral
Packaging: 20mg
Price: $320
Updated: 2021/12/16

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demethylzeylasteral Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.

Uses

Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.

Definition

ChEBI: A carbopolycyclic compound with formula C29H36O6, originally isolated from Tripterygium wilfordii.

in vivo

Demethylzeylasteral (30 mg/kg, 6 times every 2 days, i.p.) inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis^[1]. Demethylzeylasteral (4 mg/kg, 5 weeks, i.p.) inhibits the invasion of triple negative breast cancer by blocking classical and non classical TGF - β signaling pathways^[2]. Demethylzeylasteral (30-120 mg/kg, 8 weeks, i.p.) improves inflammation in a unilateral ureteral obstruction rat model by inhibiting the activation of the NF - κ B pathway^[4]. Demethylzeylasteral (10, 40 mg/kg, 30 days, i.g.) can alleviate atherosclerosis in AS rabbits^[5]. Demethylzeylasteral (10, 20 mg/kg, 4 weeks, p.o.) improves CCl4 induced liver fibrosis in mice by inhibiting AGAP2 mediated FAK/AKT signaling^[6].

Animal Model:	Female nude mice modeled with glioma LN-229 cells^[1].
Dosage:	30 mg/kg, 6 times every 2 days
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced tumor volume

Animal Model:	Female BALB/c mice modeled with 4T1 cells^[2].
Dosage:	4 mg/kg, 5 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced cancer lung metastasis

Animal Model:	Rat model of unilateral ureteral obstruction^[4].
Dosage:	30-120 mg/kg, 8 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Inhibited the increases in serum creatinine, blood urea nitrogen and Up/Ucr ratio

Animal Model:	Atherosclerotic rabbit^[5].
Dosage:	10, 40 mg/kg, 30 days
Administration:	Intragastrical (i.g.)
Result:	Reduced blood lipids triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C)

Animal Model:	CCl4-induced liver fibrosis model^[6].
Dosage:	10, 20 mg/kg, 4 weeks
Administration:	Oral gavage (p.o.)
Result:	Inhibited the expression of TGF-β1

demethylzeylasteral Preparation Products And Raw materials

Raw materials

Preparation Products

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demethylzeylasteral Suppliers

China 176 India 2 United Kingdom 1 United States 10 Global 189

Chembest Research Laboratories Limited

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Chengdu Biopurify Phytochemicals Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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View Lastest Price from demethylzeylasteral manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: demethylzeylasteral 107316-88-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2025-06-27

Shanghai Standard Technology Co., Ltd.

Product: Demethylzeylasteral 107316-88-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-13

Career Henan Chemical Co

Product: demethylzeylasteral 107316-88-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

107316-88-1, demethylzeylasteralRelated Search:

Celastrol Triptonide WILFORLIDE A tripterifordin TRIPTOPHENOLIDE WILFORDINE Triptolide wilfortrine WILFORINE

demethylzeylasteral

(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid

A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid

Demethylzeylasteral(T-96)

24,25,26-Trinoroleana-1,3,5(10),7-tetraen-29-oic acid, 2,3-dihydroxy-9,13-dimethyl-6,23-dioxo-, (9β,13α,14β,20α)-

(2R,4AS,6aS,12bR,14aS,14bR)-9-formyl-10,11-dihydroxy-2,4a,6a,12b,14a-pentamethyl-8-oxo-1,2,3,4,4a,5,6,6a,8,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid

Demethylzeylasteral-RM

Demethylzeylasteral, 10 mM in DMSO

107316-88-1

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract